| Exercise stress testing in recently abstinent chronic cocaine abusers. | |
| | |
MedLine Citation:
|
PMID: 18584578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We compared treadmill exercise stress testing (EST) in 28 medically screened, chronic cocaine users with the cardiovascular effects of an IV cocaine challenge (25 mg or 50 mg). All subjects had a clinically normal EST and echocardiography (except 2 subjects had septal wall hypokinesis). The EST produced significantly greater increases in heart rate and rate-pressure product than did the cocaine challenges. These findings suggest that EST may not provide additional diagnostic information in medically screened cocaine users. EST may cause more cardiac work (indicated by heart rate and blood pressure) than intravenous cocaine (at the doses in this study). |
| | |
Authors:
|
Praveen Kanneganti; Richard A Nelson; Susan J Boyd; Roy C Ziegelstein; David A Gorelick |
Related Documents
:
|
1274588 - The role of thymus for the development and prognosis of hypertension and hypertensive v... 8008698 - Physicomechanical characterization of the extrusion-spheronization process. i. instrume... 6545038 - Screening, treatment and adherence to treatment for hypertension. 12498268 - Rapid screening of pka values of pharmaceuticals by pressure-assisted capillary electro... 16150278 - Profound hypotension and associated electrocardiographic changes during prolonged cord ... 12388428 - Glutamate receptors in rvlm modulate sympathetic baroreflex in conscious rabbits. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
|
Title: The American journal of drug and alcohol abuse Volume: 34 ISSN: 1097-9891 ISO Abbreviation: Am J Drug Alcohol Abuse Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-06-27 Completed Date: 2008-08-14 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7502510 Medline TA: Am J Drug Alcohol Abuse Country: United States |
Other Details:
|
Languages: eng Pagination: 489-98 Citation Subset: IM |
Affiliation:
|
Department of Health and Human Services, Office of the Science Director, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224-2816, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cardiovascular Diseases / chemically induced*, epidemiology, physiopathology* Chronic Disease Cocaine / administration & dosage, adverse effects* Cocaine-Related Disorders / rehabilitation* Dose-Response Relationship, Drug Echocardiography Exercise Test* Female Heart Rate* / drug effects Humans Male Patient Compliance* Substance Abuse, Intravenous / rehabilitation* |
| Grant Support | |
ID/Acronym/Agency:
|
Z01 DA000241-15/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
50-36-2/Cocaine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sex differences in non-reinforced responding for cocaine.
Next Document: Non-fatal overdose among a cohort of active injection drug users recruited from a supervised injecti...