| Exercise stress echocardiography for the study of the pulmonary circulation. | |
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MedLine Citation:
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PMID: 19926746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise stress tests have been used for the diagnosis of pulmonary hypertension, but with variable protocols and uncertain limits of normal. The pulmonary haemodynamic response to progressively increased workload and recovery was investigated by Doppler echocardiography in 25 healthy volunteers aged 19-62 yrs (mean 36 yrs). Mean pulmonary artery pressure ((Ppa)) was estimated from the maximum velocity of tricuspid regurgitation. Cardiac output (Q) was calculated from the aortic velocity-time integral. Slopes and extrapolated pressure intercepts of (Ppa)-Q plots were calculated after using the adjustment of Poon for individual variability. A pulmonary vascular distensibility alpha was calculated from each (Ppa)-Q plot to estimate compliance. (Ppa) increased from 14+/-3 mmHg to 30+/-7 mmHg, and decreased to 19+/-4 mmHg after 5 min recovery. The slope of (Ppa)-Q was 1.37+/-0.65 mmHg x min(-1) x L(-1) with an extrapolated pressure intercept of 8.2+/-3.6 mmHg and an alpha of 0.017+/-0.018 mmHg(-1). These results agree with those of previous invasive studies. Multipoint (pa)-Q plots were well described by a linear approximation, from which resistance can be calulated. We conclude that exercise echocardiography of the pulmonary circulation is feasible and provides realistic resistance and compliance estimations. Measurements during recovery are unreliable because of rapid return to baseline. |
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Authors:
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P Argiento; N Chesler; M Mulè; M D'Alto; E Bossone; P Unger; R Naeije |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies Date: 2009-11-19 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 35 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-09-08 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1273-8 Citation Subset: IM |
Affiliation:
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Dept of Cardiology, Second University of Naples, Naples, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiac Output / physiology Echocardiography, Doppler / methods*, standards* Exercise Test / methods*, standards* Feasibility Studies Female Humans Hypertension, Pulmonary / ultrasonography Lung Compliance / physiology Male Middle Aged Models, Biological Pulmonary Artery / physiology Pulmonary Circulation / physiology* Reference Values Reproducibility of Results Rest / physiology Vascular Resistance / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL086939-01A1/HL/NHLBI NIH HHS; R01 HL086939-02/HL/NHLBI NIH HHS; R01 HL086939-03/HL/NHLBI NIH HHS; R01 HL086939-03S1/HL/NHLBI NIH HHS; R01HL086939/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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