Document Detail


Exercise stress alters the percentage of splenic lymphocyte subsets in response to mitogen but not in response to interleukin-1.
MedLine Citation:
PMID:  2790228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Results of previous work from this laboratory demonstrated that reduced murine splenic lymphocyte proliferation in response to Concanavalin A (Con A) is associated with acute exercise stress. The present study was conducted to determine whether the stress of physical work further affects the expression of splenic lymphocyte phenotypes following in vitro stimulation by the T-cell mitogen, Con A, and also by interleukin-1 (IL1). Mice in this study were assigned to one of five treatment conditions. Two groups of mice were exposed only to the noise and vibration of a treadmill for 8 weeks; one of these groups was given an acute exhaustive run. Three groups of mice were exposed to 8 weeks of treadmill training: one group was sacrificed immediately after training, a second group was sacrificed 72 h after training, and a third group was rested for 72 h and then given an acute exhaustive run. There was a significant effect of stimulation by Con A on the percentage of splenic lymphocytes positive for Thy1.2, Lyt-2, L3T4, and goat anti-mouse Ig, regardless of treatment condition. Acute exercise, however, affected the magnitude of the response. There was a significantly greater increase in the percentage of Thy1.2+ and, especially of, Lyt-2+ cells in stimulated splenic lymphocytes from untrained mice given an exhaustive exercise session compared with controls and with trained mice. There was no significant effect of the addition of IL1 to any culture, irrespective of treatment condition. These results suggest that reduced mitogenesis after acute exercise stress exposure may be related to the increased appearance of Lyt-2+ (T suppressor) cells.
Authors:
J A Randall Simpson; L Hoffman-Goetz; R Thorne; Y Arumugam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  3     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-11-17     Completed Date:  1989-11-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-28     Citation Subset:  IM    
Affiliation:
Department of Health Studies, University of Waterloo, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / diagnostic use
Antigens, Differentiation, T-Lymphocyte / metabolism*
Concanavalin A / pharmacology*
Interleukin-1 / pharmacology*
Lymphocytes / drug effects,  immunology,  physiology*
Male
Mice
Mice, Inbred C3H
Mitogens / pharmacology*
Physical Exertion*
Spleen / immunology*,  physiology
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Differentiation, T-Lymphocyte; 0/Interleukin-1; 0/Mitogens; 11028-71-0/Concanavalin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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