| Exercise skeletal muscle blood flow is related to peripheral microvascular stiffness in idiopathic dilated cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 10527769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Peripheral microvascular function plays an important role in congestive heart failure (CHF). Decreased exercise blood flow and microvascular dysfunction have been described in CHF and both factors are regarded as parameters that might influence exercise capacity in these patients. Whether these factors are related to or can be characterized in clinical severity of CHF has not been elucidated in this population. Skeletal muscle blood flow (SMBF) was measured continuously noninvasively, by means of the local isotope washout technique using (133)Xenon, in musculus tibialis anterior during graded maximal supine bicycle exercise. The distensibility in skeletal muscle was measured in a papaverine-relaxed vascular bed using (99m)Tc-pertechnetate. The investigation included 20 patients with moderate CHF (NYHA II), 11 patients with severe CHF (NYHA III, IV) due to idiopathic dilated cardiomyopathy (IDCM), and 31 age-matched healthy subjects. The maximal SMBF level was significantly lower in severe CHF (3.6 +/- 2.5 (ml x (100 g x min)(-1))) compared with moderate CHF (8.6 +/- 5.1 (ml x (100 g x min)(-1)); P < 0.005) and controls (11.0 +/- 4.1 (ml x (100 g x min)(-1)); P < 0.0001), but similar between moderate CHF and controls. Distensibility in skeletal muscle was decreased in severe CHF (12 +/- 8%) compared with controls (44 +/- 17%; P < 0.0001 vs severe CHF) and decreased with increasing severity of CHF (moderate CHF, 23 +/- 14%; P < 0.0005 vs controls). In CHF patients, a relationship was demonstrated between skeletal muscle distensibility and the maximal SMBF (P < 0.0001; r = 0.70). Moreover, maximal SMBF correlated directly to exercise time (P < 0.005; r = 0.54). Patients with CHF have reduced exercise SMBF, which may be a limiting factor for the reduced maximal exercise capacity. Moreover, microvascular distensibility in skeletal muscle is reduced and correlates to maximal exercise SMBF. Furthermore, maximal SMBF correlates to exercise time. This implies that increased skeletal muscle microvascular stiffness may contribute to the reduced blood flow during exercise and SMBF may partly limit exercise performance in CHF patients due to IDCM. |
| | |
Authors:
|
V B Sørensen; H Wroblewski; S Galatius; S Haunsø; J Kastrup |
Related Documents
:
|
3664989 - Skeletal muscle metabolism in patients with congestive heart failure: relation to clini... 18296829 - Comparison of the effects of carvedilol and metoprolol on exercise ventilatory efficien... 14658999 - Does physical training increase insulin sensitivity in chronic heart failure patients? 3602219 - Selective enlargement of the third ventricle found in chronic schizophrenia. 11896019 - Exercise training normalizes altered calcium-handling proteins during development of he... 8041679 - Exercise training in patients with congestive heart failure. how to achieve benefits sa... 21555729 - Behavioral therapy to treat urinary incontinence in parkinson disease. 19650379 - Specific circuit training in young judokas: effects of rest duration. 22446679 - The effect of resistance exercise on p53, caspase-9, and caspase-3 in trained and untra... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Microvascular research Volume: 58 ISSN: 0026-2862 ISO Abbreviation: Microvasc. Res. Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 1999-12-10 Completed Date: 1999-12-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 268-80 Citation Subset: IM; S |
Copyright Information:
|
Copyright 1999 Academic Press. |
Affiliation:
|
The Heart Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DK-2100, Denmark. vbs@dadlnet.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Flow Velocity Cardiac Output Cardiomyopathy, Dilated / physiopathology* Case-Control Studies Exercise / physiology* Exercise Test Female Humans Male Microcirculation / physiopathology Middle Aged Muscle, Skeletal / blood supply* Supine Position |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Experimental studies on the endothelium ultrastructure of heart capillaries under moderate (28-30 de...
Next Document: A new view of Starling's hypothesis at the microstructural level.