| Exercise responses of elderly patients with diastolic versus systolic heart failure. | |
| | |
MedLine Citation:
|
PMID: 12972865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Little information is available regarding peak and submaximal exercise performance in elderly heart failure (HF) patients, particularly in those with diastolic dysfunction (DD). Therefore, the purpose of this investigation was to compare exercise responses of elderly patients with HF due to either systolic dysfunction (SD) or DD, to age-matched healthy volunteers (HV). METHODS: Patients with chronic HF > or = 60 yr (N = 119) due to SD (N = 60) or primary DD (N = 59) underwent a maximal cycle ergometry test with expired gas analysis and venous lactate measurement. Twenty-eight HV > or = 60 yr served as a control group. Anaerobic threshold was determined by gas analysis (ATVEN) and by plasma lactate rise (ATLAC). RESULTS: Peak oxygen consumption (VO(2peak)) was significantly (P < 0.001) reduced in both SD and DD patients (13 +/- 0.4 vs 14 +/- 0.4 ml x kg(-1) x min(-1), respectively) versus HV (20 +/- 0.6 ml x kg(-1) x min(-1)). Peak heart rate was reduced in patients versus HV (131 +/- 3 bpm vs 145 +/- 4, respectively; P < or = 0.01), but heart rate at a given submaximal work rate was significantly lower (P < or = 0.01) in HV than in SD and DD patients. ATVEN of 11.8 +/- 0.3 ml x kg(-1) x min(-1) for HV was significantly higher than SD (8.9 +/- 0.2) and DD (9.2 +/- 0.3). Peak lactate concentration was 6.6 +/- 0.6 mmol x kg(-1) x l(-1) in HV and was significantly reduced in both SD and DD HF patients. ATVEN correlated well with ATLAC in HV and in DD patients, but not in SD patients. CONCLUSIONS: Submaximal and peak exercise performance are markedly altered in elderly HF patients compared with age-matched HV but do not appear to be different between SD and DD patients. |
| | |
Authors:
|
Peter H Brubaker; Christian T Marburger; Timothy M Morgan; Brittany Fray; Dalane W Kitzman |
Related Documents
:
|
15162245 - Effect of acute hypoxia on heart rate variability at rest and during exercise. 12618305 - Time-dependent depotentiation in the dentate gyrus of freely moving rats by repeated br... 15994855 - Low-intensity exercise training delays onset of decompensated heart failure in spontane... 15521555 - Short-term physical training alters cardiovascular autonomic response amplitude and lat... 15204425 - Early effects of extracorporeal shock-wave lithotripsy exposure on testicular sperm mor... 1854035 - Visceral losses of desflurane, isoflurane, and halothane in swine. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Medicine and science in sports and exercise Volume: 35 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2003 Sep |
Date Detail:
|
Created Date: 2003-09-15 Completed Date: 2004-01-06 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
|
Languages: eng Pagination: 1477-85 Citation Subset: IM; S |
Affiliation:
|
Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA. brubaker@wfu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aging / physiology* Anaerobic Threshold* Diastole Exercise / physiology* Exercise Tolerance Female Heart Failure / physiopathology* Humans Lactic Acid / blood Male Middle Aged Systole |
| Grant Support | |
ID/Acronym/Agency:
|
AG12257/AG/NIA NIH HHS; AG18915/AG/NIA NIH HHS; MO1RR07122/RR/NCRR NIH HHS; P60AG10484/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exercise and diastolic function after myocardial infarction.
Next Document: Functional capability is enhanced with semitendinosus than patellar tendon ACL repair.