Document Detail


Exercise responses of elderly patients with diastolic versus systolic heart failure.
MedLine Citation:
PMID:  12972865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Little information is available regarding peak and submaximal exercise performance in elderly heart failure (HF) patients, particularly in those with diastolic dysfunction (DD). Therefore, the purpose of this investigation was to compare exercise responses of elderly patients with HF due to either systolic dysfunction (SD) or DD, to age-matched healthy volunteers (HV). METHODS: Patients with chronic HF > or = 60 yr (N = 119) due to SD (N = 60) or primary DD (N = 59) underwent a maximal cycle ergometry test with expired gas analysis and venous lactate measurement. Twenty-eight HV > or = 60 yr served as a control group. Anaerobic threshold was determined by gas analysis (ATVEN) and by plasma lactate rise (ATLAC). RESULTS: Peak oxygen consumption (VO(2peak)) was significantly (P < 0.001) reduced in both SD and DD patients (13 +/- 0.4 vs 14 +/- 0.4 ml x kg(-1) x min(-1), respectively) versus HV (20 +/- 0.6 ml x kg(-1) x min(-1)). Peak heart rate was reduced in patients versus HV (131 +/- 3 bpm vs 145 +/- 4, respectively; P < or = 0.01), but heart rate at a given submaximal work rate was significantly lower (P < or = 0.01) in HV than in SD and DD patients. ATVEN of 11.8 +/- 0.3 ml x kg(-1) x min(-1) for HV was significantly higher than SD (8.9 +/- 0.2) and DD (9.2 +/- 0.3). Peak lactate concentration was 6.6 +/- 0.6 mmol x kg(-1) x l(-1) in HV and was significantly reduced in both SD and DD HF patients. ATVEN correlated well with ATLAC in HV and in DD patients, but not in SD patients. CONCLUSIONS: Submaximal and peak exercise performance are markedly altered in elderly HF patients compared with age-matched HV but do not appear to be different between SD and DD patients.
Authors:
Peter H Brubaker; Christian T Marburger; Timothy M Morgan; Brittany Fray; Dalane W Kitzman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  35     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-15     Completed Date:  2004-01-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1477-85     Citation Subset:  IM; S    
Affiliation:
Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA. brubaker@wfu.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / physiology*
Anaerobic Threshold*
Diastole
Exercise / physiology*
Exercise Tolerance
Female
Heart Failure / physiopathology*
Humans
Lactic Acid / blood
Male
Middle Aged
Systole
Grant Support
ID/Acronym/Agency:
AG12257/AG/NIA NIH HHS; AG18915/AG/NIA NIH HHS; MO1RR07122/RR/NCRR NIH HHS; P60AG10484/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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