Document Detail

Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension.
MedLine Citation:
PMID:  16982941     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulmonary hypertension (PH) is associated with restricted physical capacity, limited quality of life, and a poor prognosis because of right heart failure. The present study is the first prospective randomized study to evaluate the effects of exercise and respiratory training in patients with severe symptomatic PH. METHODS AND RESULTS: Thirty patients with PH (21 women; mean age, 50+/-13 years; mean pulmonary artery pressure, 50+/-15 mm Hg; mean World Health Organization [WHO] class, 2.9+/-0.5; pulmonary arterial hypertension, n=23; chronic thromboembolic PH, n=7) on stable disease-targeted medication were randomly assigned to a control (n=15) and a primary training (n=15) group. Medication remained unchanged during the study period. Primary end points were the changes from baseline to week 15 in the distance walked in 6 minutes and in scores of the Short Form Health Survey quality-of-life questionnaire. Changes in WHO functional class, Borg scale, and parameters of echocardiography and gas exchange also were assessed. At week 15, patients in the primary and secondary training groups had an improved 6-minute walking distance; the mean difference between the control and the primary training group was 111 m (95% confidence interval, 65 to 139 m; P<0.001). Exercise training was well tolerated and improved scores of quality of life, WHO functional class, peak oxygen consumption, oxygen consumption at the anaerobic threshold, and achieved workload. Systolic pulmonary artery pressure values at rest did not change significantly after 15 weeks of exercise and respiratory training (from 61+/-18 to 54+/-18 mm Hg) within the training group. CONCLUSIONS: This study indicates that respiratory and physical training could be a promising adjunct to medical treatment in severe PH. The effects add to the beneficial results of modern medical treatment.
Derliz Mereles; Nicola Ehlken; Sandra Kreuscher; Stefanie Ghofrani; Marius M Hoeper; Michael Halank; F Joachim Meyer; Gabriele Karger; Jan Buss; Jana Juenger; Nicole Holzapfel; Christian Opitz; Jörg Winkler; Felix F J Herth; Heinrike Wilkens; Hugo A Katus; Horst Olschewski; Ekkehard Grünig
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-09-18
Journal Detail:
Title:  Circulation     Volume:  114     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-03     Completed Date:  2006-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1482-9     Citation Subset:  AIM; IM    
Department of Cardiology and Pneumology, University of Heidelberg, Heidelberg, Germany.
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MeSH Terms
Chronic Disease
Exercise / physiology*
Exercise Therapy*
Hypertension, Pulmonary / rehabilitation,  therapy*
Middle Aged
Oxygen Consumption
Quality of Life*
Respiratory Function Tests
Respiratory Therapy*
Comment In:
Circulation. 2006 Oct 3;114(14):1448-9   [PMID:  17015802 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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