| Exercise-related hypoglycemia in diabetes mellitus. | |
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MedLine Citation:
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PMID: 21339838 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Current recommendations are that people with Type 1 and Type 2 diabetes mellitus exercise regularly. However, in cases in which insulin or insulin secretagogues are used to manage diabetes, patients have an increased risk of developing hypoglycemia, which is amplified during and after exercise. Repeated episodes of hypoglycemia blunt autonomic nervous system, neuroendocrine and metabolic defenses (counter-regulatory responses) against subsequent episodes of falling blood glucose levels during exercise. Likewise, antecedent exercise blunts counter-regulatory responses to subsequent hypoglycemia. This can lead to a vicious cycle, by which each episode of either exercise or hypoglycemia further blunts counter-regulatory responses. Although contemporary insulin therapies cannot fully mimic physiologic changes in insulin secretion, people with diabetes have several management options to avoid hypoglycemia during and after exercise, including regularly monitoring blood glucose, reducing basal and/or bolus insulin, and consuming supplemental carbohydrates. |
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Authors:
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Lisa M Younk; Maia Mikeladze; Donna Tate; Stephen N Davis |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Expert review of endocrinology & metabolism Volume: 6 ISSN: 1744-6651 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-2-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278293 Medline TA: Expert Rev Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: 93-108 Citation Subset: - |
Affiliation:
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Department of Medicine, University of Maryland School of Medicine, 10-055 Bressler Research Building, 655 West Baltimore Street, Baltimore, MD 21201, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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P01 HL056693-14//NHLBI NIH HHS; R01 DK069803-01//NIDDK NIH HHS; R01 DK069803-02//NIDDK NIH HHS; R01 DK069803-03//NIDDK NIH HHS; R01 DK069803-04//NIDDK NIH HHS; R01 DK069803-05//NIDDK NIH HHS; R01 DK069803-06//NIDDK NIH HHS |
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