Document Detail


Exercise rehabilitation in patients with cancer.
MedLine Citation:
PMID:  22392097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Emerging evidence indicates that patients with cancer have considerable impairments in cardiorespiratory fitness, which is likely to be a result of the direct toxic effects of anticancer therapy as well as the indirect consequences secondary to therapy (for example, deconditioning). This reduced cardiorespiratory fitness is associated with heightened symptoms, functional dependence, and possibly with an increased risk of cardiovascular morbidity and mortality. Current understanding of the complex interaction between the effects of the tumour and cancer-associated therapies on the organ components that govern cardiorespiratory fitness, and the effects of exercise training on these parameters is limited; further research will be critical for further progress of exercise-based rehabilitation in the oncology setting. We assess the current evidence regarding the level, mechanisms, and clinical importance of diminished cardiorespiratory fitness in patients with cancer. The efficacy and adaptations to exercise training to prevent and/or mitigate dysfunction in conjunction with exercise prescription considerations for clinical use are also discussed.
Authors:
Susan G Lakoski; Neil D Eves; Pamela S Douglas; Lee W Jones
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-06
Journal Detail:
Title:  Nature reviews. Clinical oncology     Volume:  9     ISSN:  1759-4782     ISO Abbreviation:  Nat Rev Clin Oncol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-27     Completed Date:  2012-09-20     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101500077     Medline TA:  Nat Rev Clin Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  288-96     Citation Subset:  IM    
Affiliation:
Vermont Cancer Center, Division of Hematology/Oncology, University of Vermont, Given E-214 - UVM363, 89 Beaumont Avenue, Burlington, VT 05405, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Exercise Therapy*
Humans
Neoplasms / prevention & control*,  rehabilitation*
Grant Support
ID/Acronym/Agency:
CA125458/CA/NCI NIH HHS; CA133895/CA/NCI NIH HHS; CA138634/CA/NCI NIH HHS; CA142566/CA/NCI NIH HHS; CA143254/CA/NCI NIH HHS; R01 CA138624/CA/NCI NIH HHS; R01 CA142566/CA/NCI NIH HHS; R21 CA125458/CA/NCI NIH HHS; R21 CA133895/CA/NCI NIH HHS; R21 CA143254/CA/NCI NIH HHS
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