| Exercise recordings for the detection of T wave alternans. Promises and pitfalls. | |
MedLine Citation:
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PMID: 9238377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite significant advances in the treatment of sudden cardiac death, many individuals still go untreated because routine clinical tests do not identify them to be at risk. Recently, a study to identify individuals at risk has shown that the presence of T wave alternans (TWA), a fluctuation in T wave morphology occurring on an every-other-beat basis, is an accurate predictor of subsequent ventricular tachyarrhythmic events. T wave alternans as low as a few microvolts was found to be significant in predicting risk. Since TWA is often detectable only at elevated heart rates, the study used atrial pacing to increase the heart rate to approximately 100 beats/min. To make TWA measurement more broadly applicable, the authors have developed a methodology that uses noninvasive physiologic stress to raise the heart rate. A particular challenge was the measurement of TWA during exercise, since the levels of noise during exercise can far exceed the levels of TWA. However, by using special multisegment Hi-Res electrodes (Cambridge Heart, Bedford, MA), noise reduction software, and a spectral method of alternans analysis, the authors have been able to reduce noise and reliably measure microvolt-level alternans. This study presents an overview of the methodology for recording and analyzing microvolt-level TWA during ergometer exercise. |
Authors:
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P Albrecht; J Arnold; S Krishnamachari; R J Cohen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of electrocardiology Volume: 29 Suppl ISSN: 0022-0736 ISO Abbreviation: J Electrocardiol Publication Date: 1996 |
Date Detail:
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Created Date: 1997-08-19 Completed Date: 1997-08-19 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 46-51 Citation Subset: IM |
Affiliation:
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Cambridge Heart, Bedford, MA 01730, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cardiomyopathy, Hypertrophic / physiopathology Electrocardiography / methods* Exercise / physiology* Exercise Test Female Heart Rate* Humans Male Predictive Value of Tests Tachycardia, Ventricular / physiopathology* |
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