Document Detail


Exercise promotes bone marrow cell survival and recipient reconstitution post-bone marrow transplantation which is associated with increased survival.
MedLine Citation:
PMID:  23063724     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bone marrow transplantation (BMT) is associated with a high risk of mortality partially due to the harmful effects of the preconditioning myeloablative regimens. We have recently demonstrated increased bone marrow cell survival and proliferation in response to exercise training, which may be attributable to increased quality of the niche. The purpose of the present study was to determine the extent to which exercise preconditioning of recipients could increase the success of BMT. Recipient mice remained sedentary (SED) or were exercise-trained on a treadmill (EX; 3d/wk, 8 wks) prior to reconstitution with GFP-labeled donor marrow. Recipient survival, both donor-derived and total (donor- and recipient-derived) blood reconstitution were measured by flow cytometry. One and four days post-BMT apoptosis, cellularity and donor cell homing were determined in the recipients' bone marrow cavity by flow cytometry. Whereas only 25% of SED survived, 82% of EX recipients survived the BMT. Homing of donor-derived marrow cells to the recipients' marrow cavity acutely post-BMT was not altered in EX, but EX mice displayed decreased levels (10%, p<0.05) of activated caspase-3/-7 one day following BMT leading to a maintenance of marrow cellularity in mice preconditioned with exercise. The acute inhibition of marrow cell apoptosis in EX resulted in increased total blood cell reconstitution at one and three and a half months post-BMT in EX (42% and 43% respectively, both p<0.05). Short- and long-term donor-derived engraftment was not different between exercise preconditioned and sedentary recipients. Exercise training increases recipient survival post-BMT with increased total blood cell reconstitution.
Authors:
Michael De Lisio; Jeff M Baker; Gianni Parise
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  Experimental hematology     Volume:  -     ISSN:  1873-2399     ISO Abbreviation:  Exp. Hematol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402313     Medline TA:  Exp Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada, L8S 4K1.
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