Document Detail


Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart.
MedLine Citation:
PMID:  18093988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: We investigated whether exercise training could promote angiogenesis and improve blood perfusion and left ventricular (LV) remodelling of the post-myocardial infarction (MI) failing heart. We also explored the contribution of ameliorated beta-adrenergic receptor signalling and function on the overall improvement of cardiac contractility reserve induced by exercise. METHODS AND RESULTS: Adult Wistar male rats were randomly assigned to one of four experimental groups. Sham-operated and post-MI heart failure (HF) rats were housed under sedentary conditions or assigned to 10-weeks of a treadmill exercise protocol. At 4 weeks after MI, sedentary HF rats showed LV eccentric hypertrophy, marked increase of LV diameters associated with severely impaired fractional shortening (14 +/- 5%), increased LV end diastolic pressure (20.9 +/- 2.6 mmHg), and pulmonary congestion. In addition, cardiac contractile responses to adrenergic stimulation were significantly blunted. In trained HF rats, exercise was able to (i) reactivate the cardiac vascular endothelial growth factor pathway with a concurrent enhancement of myocardial angiogenesis, (ii) significantly increase myocardial perfusion and coronary reserve, (iii) reduce cardiac diameters, and (iv) improve LV contractility in response to adrenergic stimulation. This latter finding was also associated with a significant improvement of cardiac beta-adrenergic receptor downregulation and desensitization. CONCLUSIONS: Our data indicate that exercise favourably affects angiogenesis and improves LV remodelling and contractility reserve in a rat model of severe chronic HF.
Authors:
Dario Leosco; Giuseppe Rengo; Guido Iaccarino; Luca Golino; Massimo Marchese; Francesca Fortunato; Carmela Zincarelli; Emma Sanzari; Michele Ciccarelli; Gennaro Galasso; Giovanna Giuseppina Altobelli; Valeria Conti; Gianfranco Matrone; Vincenzo Cimini; Nicola Ferrara; Amelia Filippelli; Walter J Koch; Franco Rengo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-18
Journal Detail:
Title:  Cardiovascular research     Volume:  78     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-08-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  385-94     Citation Subset:  IM    
Affiliation:
Cattedra di Geriatria, Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Via Pansini 5, 80131 Napoli, Italy. dleosco@unina.it
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology
Animals
Coronary Circulation
Coronary Vessels / drug effects,  metabolism,  physiopathology*
Disease Models, Animal
Dose-Response Relationship, Drug
Heart Failure / etiology,  metabolism,  physiopathology*,  ultrasonography
Isoproterenol / pharmacology
Male
Myocardial Contraction
Myocardial Infarction / complications*,  metabolism,  physiopathology,  ultrasonography
Myocardium / enzymology,  metabolism*,  pathology
Neovascularization, Physiologic* / drug effects
Nitric Oxide Synthase Type II / metabolism
Nitric Oxide Synthase Type III
Physical Exertion*
Proto-Oncogene Proteins c-akt / metabolism
Rats
Rats, Wistar
Receptors, Adrenergic, beta / drug effects,  metabolism*
Signal Transduction* / drug effects
Time Factors
Vascular Endothelial Growth Factor A / metabolism
Ventricular Function, Left
Ventricular Remodeling
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Receptors, Adrenergic, beta; 0/Vascular Endothelial Growth Factor A; 7683-59-2/Isoproterenol; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.14.13.39/Nos3 protein, rat; EC 2.7.11.1/Proto-Oncogene Proteins c-akt

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