| Exercise prevents the effects of experimental arthritis on the metabolism and function of immune cells. | |
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MedLine Citation:
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PMID: 20517889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Active lymphocytes (LY) and macrophages (MPhi) are involved in the pathophysiology of rheumatoid arthritis (RA). Due to its anti-inflammatory effect, physical exercise may be beneficial in RA by acting on the immune system (IS). Thus, female Wistar rats with type II collagen-induced arthritis (CIA) were submitted to swimming training (6 weeks, 5 days/week, 60 min/day) and some biochemical and immune parameters, such as the metabolism of glucose and glutamine and function of LY and MPhi, were evaluated. In addition, plasma levels of some hormones and of interleukin-2 (IL-2) were also determined. Results demonstrate that CIA increased lymphocyte proliferation (1.9- and 1.7-fold, respectively, in response to concanavalin A (ConA) and lipopolysaccharide (LPS)), as well as macrophage H(2)O(2) production (1.6-fold), in comparison to control. Exercise training prevented the activation of immune cells, induced by CIA, and established a pattern of substrate utilization similar to that described as normal for these cells. Exercise also promoted an elevation of plasma levels of corticosterone (22.2%), progesterone (1.7-fold) and IL-2 (2.6-fold). Our data suggest that chronic exercise is able to counterbalance the effects of CIA on cells of the IS, reinforcing the proposal that the benefits of exercise may not be restricted to aerobic capacity and/or strength improvement. |
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Authors:
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Francisco Navarro; Aline V N Bacurau; Sandro S Almeida; Carlos C Barros; Milton R Moraes; Jorge L Pesquero; Sandra M L Ribeiro; Ronaldo C Araújo; Luis F B P Costa Rosa; Reury F P Bacurau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biochemistry and function Volume: 28 ISSN: 1099-0844 ISO Abbreviation: Cell Biochem. Funct. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: England |
Other Details:
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Languages: eng Pagination: 266-73 Citation Subset: IM |
Copyright Information:
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2010 John Wiley & Sons, Ltd. |
Affiliation:
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Institute of Biomedical Sciences, University of São Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arthritis, Experimental / chemically induced, metabolism*, prevention & control Cattle Collagen Type II / toxicity Corticosterone / blood Female Glucose / metabolism Glutamine / metabolism Interleukin-2 / blood Lymphocytes / immunology, metabolism*, physiology Macrophages / immunology, metabolism*, physiology Physical Conditioning, Animal* Progesterone / blood Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Collagen Type II; 0/Interleukin-2; 50-22-6/Corticosterone; 50-99-7/Glucose; 56-85-9/Glutamine; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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