Document Detail


Exercise pre-conditioning strengthens brain microvascular integrity in a rat stroke model.
MedLine Citation:
PMID:  16551437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increasing evidence indicates that physical activity reduces brain damage after stroke. The purpose of this study was to determine whether exercise-induced neuroprotection is associated with improved brain integrity in stroke. Adult male Sprague-Dawley rats (3 months old, n=38) exercised on a treadmill, which required repetitive locomotor movement, for 30 minutes each day for 3 weeks. Then, using an intraluminal filament, stroke was induced by either 2 hours middle cerebral artery (MCA) occlusion followed by 24 or 48 hours of reperfusion. Brain damage was determined by evaluating brain infarction and brain edema, as well as ultrastructural alteration in endothelial-matrix-astrocyte interfaces.Pre-ischemic motor exercise significantly (p<0.01) reduced infarct volume in the frontoparietal cortex and the dorsolateral striatum by 79%. By comparing the percentage difference in brain volume between the right (stroke site) and left hemispheres, we demonstrated a significant (p<0.01) reduction in brain edema associated with reduced infarct volume in a 3 week exercise group (Group 1, n=10) and a 3 week exercise plus 3 week rest group (Group 2, n=10). Edema in cortex and striatum was 19 +/- 4% without exercise pre-conditioning (n=10), in contrast to 5 +/- 3% (Group 1) or 6 +/- 4% (Group 2). The thickness of the basal lamina was enhanced by exercise. In ischemic rats without pre-exercise, alterations in microvessel ultrastructure with decreased luminal area, parenchymal edema and swollen astrocyte end-feet, as well as an abnormally thin basal lamina were observed. In contrast, exercise pre-conditioning significantly reduced the ischemic alterations, decreasing brain edema and increasing basal lamina thickness. This study suggests that exercise pre-conditioning reduces brain injury by decreasing cerebral permeability and enhancing brain integrity after stroke. This exercise-induced endogenous neuroprotection could be an effective strategy to ameliorate ischemic brain injury from stroke.
Authors:
Yun-Hong Ding; Yuchuan Ding; Jie Li; Denise A Bessert; José A Rafols
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurological research     Volume:  28     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-05-22     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  184-9     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Wayne State University School of Medicine, USA. dingy2@uthscsa.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / pathology
Basement Membrane / pathology,  physiopathology
Blood-Brain Barrier / physiology*
Brain Edema / physiopathology,  prevention & control,  rehabilitation
Cerebral Arteries / pathology,  physiopathology*
Cerebrovascular Circulation / physiology*
Disease Models, Animal
Endothelial Cells / pathology
Female
Infarction, Middle Cerebral Artery / physiopathology,  rehabilitation
Male
Microcirculation / pathology,  physiopathology*
Microscopy, Electron, Transmission
Physical Conditioning, Animal / methods,  physiology*
Rats
Rats, Sprague-Dawley
Reperfusion Injury / physiopathology,  rehabilitation
Stroke / physiopathology,  rehabilitation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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