| Exercise performance increases coincident to body weight over the first two years following cardiac transplantation. | |
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MedLine Citation:
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PMID: 21355882 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chaudry H, Yip DS, Bush T, Reynolds V, Witzke L, Taylor V, Hosenpud JD. Exercise performance increases coincident to body weight over the first two years following cardiac transplantation. Clin Transplant 2011 DOI: 10.1111/j.1399-0012.2011.01410.x. © 2011 John Wiley & Sons A/S. Abstract: Background: To determine whether exercise performance changed over time once patients stabilized after heart transplantation, metabolic stress testing was performed in patients one and two yr post-heart transplantation. Methods: The patient cohort includes those transplanted in our program who survived at least two yr and were able to perform metabolic stress tests during their one- and two-yr annual evaluations. Standard stress test parameters were assessed, including weight, body surface area, rest and exercise heart rate (HR) and blood pressure (BP), exercise time, anaerobic threshold (AT), and maximum VO2 (MVO2). Ejection fraction by echo was also collected. Each patient served as their own control and data were compared using paired t-testing. Results: Fifty patients were included in the cohort, 48 of whom were able to exercise to at least AT. Patient weight increased from year 1 to year 2 (82.4 ± 15.1 vs. 85.0 ± 17.0 kg, p = 0.035). Systolic BP increased approximately 40 mmHg with exercise with no change in diastolic BP, and there was no difference between years 1 and 2. HR increased approximately 25 bpm with exercise. There was no difference in resting HR but exercise HR increased significantly between yrs (148 ± 15 bpm vs. 154 ± 18 bpm, p = 0.017). Both VO2 at AT and MVO2 increased significantly from year 1 to year 2 (1116 ± 347 mL/min vs. 1192 ± 313 mL/min, p = 0.049 and 1523 ± 337 mL/min vs. 1599 ± 356 mL/min, p = 0.012, respectively) but when corrected for body weight, there were no differences (VO2-AT 13.6 ± 4.0 mL/kg/min vs. 14.0 ± 4.0 mL/kg/min; MVO2 18.7 ± 4.2 mL/kg/min vs. 18.8 ± 4.1 mL/kg/min). All other measured parameters were not different. There was a weak but statistically significant correlation between change in peak HR and change in VO2 at AT between one and two yr post-transplantation (r = 0.30, p = 0.04). Conclusions: We conclude that exercise performance as measured by VO2 can increase over time post-heart transplantation and in our cohort appears to be related to both an increase in body weight and an increase in HR from years 1 and 2. |
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Authors:
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Hannah Chaudry; Daniel S Yip; Tanya Bush; Virginia Reynolds; Lorraine Witzke; Virginia Taylor; Jeffrey D Hosenpud |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-28 |
Journal Detail:
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Title: Clinical transplantation Volume: - ISSN: 1399-0012 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710240 Medline TA: Clin Transplant Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Transplantation, Mayo Clinic Florida, Jacksonville, FL, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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