| Exercise performance in patients with pulmonary hypertension linked to cardiac magnetic resonance measures. | |
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MedLine Citation:
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PMID: 19716042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The 6-minute walk distance (6MWD) is a useful measure of functional class and has been shown to predict mortality in patients with pulmonary hypertension (PH). Determinants of functional class in PH are incompletely understood. We hypothesized that cardiovascular structure and function, as determined by cardiac magnetic resonance (CMR) imaging, and cardiac hemodynamics, as determined by right heart catheterization (RHC), would predict 6MWD in adult patients with PH. METHODS: Forty-three patients (32 women) with PH underwent RHC, CMR and 6MWD testing within a 3-month period. The 6MWD was correlated with RHC and CMR variables using Spearman rho (r) coefficients. These relationships were further evaluated using linear regression analysis. RESULTS: Median 6MWD was 233.2 (interquartile range 161.6 to 338.4) meters. The 6MWD was correlated with pulmonary artery (PA) elasticity (r = 0.42, p = 0.006), PA average blood flow velocity (r = 0.38, p = 0.014), right ventricular stroke volume index (RVSVI; r = 0.41, p = 0.008), left ventricular SVI (LVSVI; r = 0.36, p = 0.018) and RV stroke work index (RVSWI; r = 0.37, p = 0.017). These associations remained significant after adjustment for age, gender, body mass index and the presence of lung disease. Exercise performance did not correlate with commonly measured indices such as ventricular volume, ejection fraction or pulmonary pressure. CONCLUSIONS: Stroke volume index, PA elasticity and PA average blood flow velocity are novel CMR parameters associated with functional class in PH. CMR can provide insights into determinants of exercise performance and may be a useful tool to non-invasively monitor cardiovascular status in patients with PH. |
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Authors:
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Gerin R Stevens; Anuradha Lala; Javier Sanz; Mario J Garcia; Valentin Fuster; Sean Pinney |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 28 ISSN: 1557-3117 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2010-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 899-905 Citation Subset: IM |
Affiliation:
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Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York, USA. grs2123@columbia.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Mass Index Exercise / physiology* Female Heart / anatomy & histology, physiopathology* Heart Catheterization Heart Diseases / complications Humans Hypertension, Pulmonary / etiology, pathology, physiopathology* Magnetic Resonance Imaging Male Regression Analysis Stroke Volume Systole Vascular Resistance Ventricular Function, Left Walking / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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