| Exercise performance and beta-adrenergic blockade in patients with complete heart block treated with ventricular inhibited pacing. | |
| | |
MedLine Citation:
|
PMID: 1742909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of beta-adrenergic blockade (propranolol) on exercise performance was studied in 15 patients (12 men and 3 women, mean age 70 years) with complete heart block treated with a ventricular-inhibited pacemaker (VVI). In a double-blind procedure, the patients were randomly given either 0.1 mg/kg of propranolol or saline solution i.v. before a first exercise test and vice versa before a second test. The interval between the tests was 24 hours. Nine patients were in sinus rhythm, 4 patients had atrial flutter, and 2 others had atrial fibrillation. The exercise capacity was on an average 11% lower with propranolol than with placebo (p less than 0.001). The most marked reductions (20 and 33%) were found in the two patients with atrial fibrillation. The atrial rate in patients with sinus rhythm was significantly lower with propranolol than placebo both at rest (68 vs. 83 beats/min, p less than 0.001) and at maximal work load (91 vs. 141 beats/min, p less than 0.001). The present findings show that beta blockade has negative effects on exercise capacity in patients with complete heart block treated with VVI pacemakers. This finding should be considered in the selection of drug treatment in patients with fixed rate pacing and concomitant hypertension and/or ischemic heart disease. |
| | |
Authors:
|
J Wikner; F F Larsen; R Nordlander; K Pehrsson; H Aström |
Related Documents
:
|
12137339 - Performance of a rate responsive accelerometer-based pacemaker with autocalibration dur... 3364359 - Use dependence of amiodarone during the sinus tachycardia of exercise in coronary arter... 7942549 - Diagnostic value of recovery time measured by body surface mapping in patients with con... 3383469 - Rate-responsive pacing with a pacemaker that detects respiratory rate (biorate): clinic... 3942059 - Effects of isoproterenol and amiodarone and the role of exercise in initiation of circu... 15826259 - Rate-dependent av delay optimization in cardiac resynchronization therapy. 17061939 - Changes in heart rate variability of athletes during a training camp. 1521949 - 'sports anemia'--a real or apparent phenomenon in endurance-trained athletes? 2818449 - Adenosine-induced increase in myocardial atp: are there beneficial effects for the isch... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Clinical cardiology Volume: 14 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1991 Sep |
Date Detail:
|
Created Date: 1992-01-14 Completed Date: 1992-01-14 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 749-52 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Combined Modality Therapy Double-Blind Method Exercise Test / drug effects* Female Heart Block / physiopathology, therapy* Heart Ventricles / drug effects, physiopathology Humans Male Middle Aged Pacemaker, Artificial* Propranolol / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diastolic pressure-volume relationship during handgrip exercise in patients with coronary artery dis...
Next Document: Catheter balloon valvuloplasty of stenotic porcine bioprosthetic valves: Part II: Mechanisms, compli...