Document Detail

Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes.
MedLine Citation:
PMID:  18678339     Owner:  NLM     Status:  MEDLINE    
The prevalence of exercise-induced bronchoconstriction is reported to be high among recreational and elite athletes, yet diagnosis is often symptom-based. Indirect challenges such as the laboratory exercise challenge provide objective criteria for proper diagnosis and treatment. However, a standardized protocol using appropriate exercise intensity, duration, and dry air inhalation is often not implemented, and thus a false-negative test may result. This article reviews and describes the symptom-based diagnosis, the exercise challenge, and other indirect challenges such as eucapnic voluntary hyperpnea, hypertonic saline inhalation, and inhaled powdered mannitol as methods to diagnose and evaluate exercise-induced bronchoconstriction. Advantages and disadvantages of each diagnostic procedure are presented.
Kenneth W Rundell; Joshua B Slee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  122     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-05     Completed Date:  2008-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-46; quiz 247-8     Citation Subset:  AIM; IM    
Human Physiology Laboratory, Keith J. O'Neill Center for Healthy Families, Marywood University, Scranton, PA 18509, USA.
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MeSH Terms
Adenosine Monophosphate / diagnostic use
Asthma, Exercise-Induced / diagnosis*
Bronchial Hyperreactivity / diagnosis*
Exercise Test
Mannitol / diagnostic use
Reg. No./Substance:
61-19-8/Adenosine Monophosphate; 69-65-8/Mannitol

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