Document Detail

Exercise for older adult inpatients with acute myelogenous leukemia: A pilot study.
MedLine Citation:
PMID:  23843929     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Acute myelogenous leukemia (AML) largely affects older adults. Few interventions have sought to improve functional status and health-related quality of life (HRQL) during treatment. The objective of this study is to examine the feasibility of an exercise intervention among older adults with AML undergoing induction chemotherapy.
MATERIALS AND METHODS: Pilot study of adults ≥50 years of age hospitalized for AML chemotherapy. The four week exercise intervention included stretching, walking, and strength exercises. Feasibility measures included recruitment, retention, number of exercise sessions completed, and barriers to participation. Physical function, HRQL, depression, and distress were assessed at baseline (week 1), upon completion of intervention (week 5), and during follow-up (weeks 9-13). Exploratory analyses used repeated measures ANCOVA to model changes over time.
RESULTS: Among 55 eligible inpatients, 24 enrolled (43.6%). Mean age was 65.1 years (SD 7.8). 87.5% of participants completed baseline measures; 70.8% attended ≥1 exercise sessions, and 50.0% completed post-intervention assessment. Among baseline characteristics, only higher physical performance was associated with greater number of exercise sessions attended (p=0.001). Post intervention, HRQL and depressive symptoms improved (p <0.05).
CONCLUSIONS: Recruitment to an exercise intervention was feasible. Exercise shows promise to maintain physical function and enhance HRQL. Strategies to enhance adherence to exercise are needed to maximize benefit.
Heidi D Klepin; Suzanne C Danhauer; Janet A Tooze; Kylie Stott; Kristin Daley; Tanya Vishnevsky; Bayard L Powell; Shannon L Mihalko
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Publication Detail:
Journal Detail:
Title:  Journal of geriatric oncology     Volume:  2     ISSN:  1879-4068     ISO Abbreviation:  J Geriatr Oncol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2013-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101534770     Medline TA:  J Geriatr Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  11-17     Citation Subset:  -    
Comprehensive Cancer Center of Wake Forest University, Department of Internal Medicine, Section on Hematology and Oncology, Winston-Salem, NC.
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