Document Detail


Exercise offers anxiolytic potential: a role for stress and brain noradrenergic-galaninergic mechanisms.
MedLine Citation:
PMID:  22771334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although physical activity reduces anxiety in humans, the neural basis for this response is unclear. Rodent models are essential to understand the mechanisms that underlie the benefits of exercise. However, it is controversial whether exercise exerts anxiolytic-like potential in rodents. Evidence is reviewed to evaluate the effects of wheel running, an experimental mode of exercise in rodents, on behavior in tests of anxiety and on norepinephrine and galanin systems in neural circuits that regulate stress. Stress is proposed to account for mixed behavioral findings in this literature. Indeed, running promotes an adaptive response to stress and alters anxiety-like behaviors in a manner dependent on stress. Running amplifies galanin expression in noradrenergic locus coeruleus (LC) and suppresses stress-induced activity of the LC and norepinephrine output in LC-target regions. Thus, enhanced galanin-mediated suppression of brain norepinephrine in runners is supported by current literature as a mechanism that may contribute to the stress-protective effects of exercise. These data support the use of rodents to study the emotional and neurobiological consequences of exercise.
Authors:
Natale R Sciolino; Philip V Holmes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-07-05
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  36     ISSN:  1873-7528     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  2013-03-14     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1965-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / metabolism,  psychology*
Brain / metabolism*
Galanin / metabolism*
Norepinephrine / metabolism*
Physical Conditioning, Animal / physiology,  psychology*
Rats
Stress, Psychological / metabolism,  psychology*
Grant Support
ID/Acronym/Agency:
DA027535A/DA/NIDA NIH HHS; DA027535AS1/AS/ASC OASH HHS
Chemical
Reg. No./Substance:
88813-36-9/Galanin; X4W3ENH1CV/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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