| Exercise for multiple sclerosis: a single-blind randomized trial comparing three exercise intensities. | |
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MedLine Citation:
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PMID: 21247971 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The most effective exercise dose has yet to be established for multiple sclerosis (MS). OBJECTIVE: The aim of this study was to investigate the effect of different exercise intensities in people with MS. METHODS: We completed a randomized comparator study of three cycling exercise intensities, with blinded assessment, was carried out in Oxford. Sixty-one adults with MS who fulfilled inclusion criteria were randomized at entry into the study, using a computer-generated list held by an exercise professional, into either: continuous (at 45% peak power, n=20), intermittent (30 sec on, 30 sec off at 90% peak power, n=21) or combined (10 min intermittent at 90% peak power then 10 min continuous at 45% peak power, n=20) exercise for 20 min twice a week for 12 weeks in a leisure facility. Groups were assessed at: baseline, halfway (6 weeks), end intervention (12 weeks) and follow-up (24 weeks). Primary outcome measure was 2 min walk. RESULTS: Fifty-five participants were included in the analysis (n=continuous 20, intermittent 18, combined 17). No differences were found between groups. After 6 weeks, considering all participants, 2 min walk distance increased by 6.96±2.56 m (95% CI: 1.81 to 12.10, effect size (es): 0.25, p<0.01). The continuous group increased by 4.71±4.24 m (95% CI: -3.80 to 13.22, es: 0.06), intermittent by 12.94±4.71 m (95% CI: 3.97 to 21.92, es: 0.28) and combined by 3.22±4.60 m (95% CI: -6.01 to 12.46, es: 0.04). Two minute walk did not significantly change between further assessments. Between 6 and 12 weeks there was a drop in attendance that seemed to be associated with the intermittent and combined groups; these groups also had a greater number of adverse events (leg pain during cycling most common) and dropouts (n=continuous 1, intermittent 5, combined 10). Considering all participants, 6 weeks of cycling exercise produced benefits in mobility that were maintained with further sessions. CONCLUSION: While no differences were found between groups, greater benefit may be associated with higher-intensity exercise, but this may be less well tolerated. CONSORT-trial registration number (ISRCTN89009719). |
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Authors:
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Johnny Collett; Helen Dawes; Andy Meaney; Cath Sackley; Karen Barker; Derick Wade; Hooshang Izardi; James Bateman; Joan Duda; Elizabeth Buckingham |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-01-19 |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 17 ISSN: 1477-0970 ISO Abbreviation: Mult. Scler. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-06-02 Completed Date: 2011-10-04 Revised Date: 2011-10-17 |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
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Languages: eng Pagination: 594-603 Citation Subset: IM |
Affiliation:
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Movement Science Group, School of Life Sciences, Oxford Brookes University, UK. jcollett@brookes.ac.uk |
| Data Bank Information | |
Bank Name/Acc. No.:
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ISRCTN/ISRCTN89009719 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Bicycling Disability Evaluation England Exercise Test Exercise Therapy* / adverse effects Female Humans Male Middle Aged Multiple Sclerosis / diagnosis, physiopathology, therapy* Patient Compliance Patient Dropouts Questionnaires Recovery of Function Single-Blind Method Time Factors Treatment Outcome Walking |
| Grant Support | |
ID/Acronym/Agency:
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840//Multiple Sclerosis Society |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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