Document Detail

Exercise for multiple sclerosis: a single-blind randomized trial comparing three exercise intensities.
MedLine Citation:
PMID:  21247971     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The most effective exercise dose has yet to be established for multiple sclerosis (MS).
OBJECTIVE: The aim of this study was to investigate the effect of different exercise intensities in people with MS.
METHODS: We completed a randomized comparator study of three cycling exercise intensities, with blinded assessment, was carried out in Oxford. Sixty-one adults with MS who fulfilled inclusion criteria were randomized at entry into the study, using a computer-generated list held by an exercise professional, into either: continuous (at 45% peak power, n=20), intermittent (30 sec on, 30 sec off at 90% peak power, n=21) or combined (10 min intermittent at 90% peak power then 10 min continuous at 45% peak power, n=20) exercise for 20 min twice a week for 12 weeks in a leisure facility. Groups were assessed at: baseline, halfway (6 weeks), end intervention (12 weeks) and follow-up (24 weeks). Primary outcome measure was 2 min walk.
RESULTS: Fifty-five participants were included in the analysis (n=continuous 20, intermittent 18, combined 17). No differences were found between groups. After 6 weeks, considering all participants, 2 min walk distance increased by 6.96±2.56 m (95% CI: 1.81 to 12.10, effect size (es): 0.25, p<0.01). The continuous group increased by 4.71±4.24 m (95% CI: -3.80 to 13.22, es: 0.06), intermittent by 12.94±4.71 m (95% CI: 3.97 to 21.92, es: 0.28) and combined by 3.22±4.60 m (95% CI: -6.01 to 12.46, es: 0.04). Two minute walk did not significantly change between further assessments. Between 6 and 12 weeks there was a drop in attendance that seemed to be associated with the intermittent and combined groups; these groups also had a greater number of adverse events (leg pain during cycling most common) and dropouts (n=continuous 1, intermittent 5, combined 10). Considering all participants, 6 weeks of cycling exercise produced benefits in mobility that were maintained with further sessions.
CONCLUSION: While no differences were found between groups, greater benefit may be associated with higher-intensity exercise, but this may be less well tolerated. CONSORT-trial registration number (ISRCTN89009719).
Johnny Collett; Helen Dawes; Andy Meaney; Cath Sackley; Karen Barker; Derick Wade; Hooshang Izardi; James Bateman; Joan Duda; Elizabeth Buckingham
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-01-19
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  17     ISSN:  1477-0970     ISO Abbreviation:  Mult. Scler.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-06-02     Completed Date:  2011-10-04     Revised Date:  2011-10-17    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  594-603     Citation Subset:  IM    
Movement Science Group, School of Life Sciences, Oxford Brookes University, UK.
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MeSH Terms
Analysis of Variance
Disability Evaluation
Exercise Test
Exercise Therapy* / adverse effects
Middle Aged
Multiple Sclerosis / diagnosis,  physiopathology,  therapy*
Patient Compliance
Patient Dropouts
Recovery of Function
Single-Blind Method
Time Factors
Treatment Outcome
Grant Support
840//Multiple Sclerosis Society

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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