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MedLine Citation:
PMID:  21515668     Owner:  NLM     Status:  Publisher    
Episodic increases in shear stress have been proposed as a mechanism which induces training-induced adaptation in arterial wall remodeling in humans. To address this hypothesis in humans, we examined bilateral brachial artery wall thickness using high-resolution ultrasound in healthy men across an 8-week period of bilateral handgrip training. Unilaterally, shear rate was attenuated by cuff inflation to 60 mmHg. Grip strength, forearm volume and girth improved similarly between the limbs. Acute bouts of handgrip exercise increased shear rate (P<0.005) in the uncuffed limb, whereas cuff inflation successfully decreased exercise-induced increases in shear. Handgrip training had no effect on baseline brachial artery diameter, blood flow or shear rate. Exercise training resulted in a significant decrease in brachial artery wall thickness after 6 and 8 weeks (ANOVA: P<0.001) and wall-to-lumen ratio after week 8 (ANOVA: P=0.005). The magnitude of decrease in brachial artery wall thickness and wall-to-lumen ratio after exercise training was similar in the uncuffed and cuffed arms. These results suggest that exercise-induced changes in shear rate are not obligatory for arterial wall remodeling during a period of 8-week exercise training in healthy humans.
Dick H J Thijssen; Ellen Adele Dawson; Inge van de Munckhof; Toni M Tinken; Evert Den Drijver; Nicola Hopkins; Nigel Timothy Cable; Daniel John Green
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-22
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1University Medical Centre Nijmegen.
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