| Exercise limitation in trained heart and kidney transplant recipients: central and peripheral limitations. | |
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MedLine Citation:
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PMID: 16297781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To evaluate the role of central and peripheral contributions to exercise limitation after transplantation, we compared, during exercise, 2 groups of very well-trained heart transplants recipients (HTRs) and kidney transplant recipients (KTRs) with a group of control subjects (CSs), matched for physical level. METHODS: Nineteen male subjects, 7 HTRs, 6 KTRs and 6 CSs, participated in the study. All transplant patients were in sinus rhythm and were matched for immunosuppressive therapy, none of whom had therapy with chronotropic effects. Exercise capacities were evaluated using a symptom-limited treadmill test. Oxygen consumption (VO2) and heart rate (HR) were measured continuously. Heart rate reserve (HRR) was defined as peak HR minus resting HR; resting HR was the stabilized HR measured in the supine position before the treadmill test. RESULTS: Functional capacities were evaluated for all HTRs, KTRs and CSs, according to maximal VO2 (41.5 +/- 4.0, 52.0 +/- 8.7 and 50.6 +/- 9.0 ml/kg per min, respectively), maximal treadmill speed (9.9 +/- 1.2, 12.7 +/- 1.9 and 15.5 +/- 1.5 km/h) and HRR (65 +/- 17, 101 +/- 12 and 110 +/- 11 beats per minute [bpm]), which were significantly lower in the HTR group (p < 0.05). Regardless of type of organ transplant, both HTR and KTR patients had a similar VO2/treadmill speed relationship, significantly higher than in the CS group. HRR correlated with maximal VO2 for HTRs (r = 0.72, p < 0.05). CONCLUSIONS: Despite regular training, the decreased mechanical efficiency reflected by an increased VO2/treadmill speed relationship suggests a peripheral limitation in both heart and kidney transplant patients. Furthermore, exercise limitations in HTRs likely arose from both central and peripheral factors, in view of their specific HRR reduction. These factors probably contributed to the decreased speed and VO2 observed in the HTR group. |
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Authors:
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Ruddy Richard; Jean-Claude Verdier; Stéphane Doutreleau; François Piquard; Bernard Gény; Michel Rieu |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-08-19 |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 24 ISSN: 1557-3117 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-21 Completed Date: 2006-06-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 1774-80 Citation Subset: IM |
Affiliation:
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Service de Physiologie et des Explorations Fonctionnelles, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. ruddy.richard@physio-ulp.u-strasbg.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exercise Tolerance / physiology* Heart Rate Heart Transplantation / physiology* Humans Kidney Transplantation / physiology* Male Middle Aged Oxygen Consumption Stroke Volume Ventricular Function, Left |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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