Document Detail

Exercise left ventricular performance in patients with mitral valve prolapse.
MedLine Citation:
PMID:  3169678     Owner:  NLM     Status:  MEDLINE    
Patients with mitral valve prolapse may, even in the absence of associated coronary artery disease or significant mitral regurgitation, have abnormality in exercise left ventricular function. The precise reason for this abnormality, which appears to be age and sex related, is not clear. Abnormal ejection fraction response to exercise cannot be predicted by the nature of symptoms, electrocardiographic changes, arrhythmias, or by extent and severity of mitral valve prolapse by echocardiography. Caution should therefore be exercised in diagnosing associated coronary artery disease based on the ejection fraction response to exercise per se or even on exercise-induced wall motion abnormality. Patients with prolapse, have reduced exercise tolerance, which has been ascribed to reduced left ventricular filling and smaller left ventricular end-diastolic volume in the upright position. Patients with mitral valve prolapse and associated coronary artery disease or significant mitral regurgitation often have, as expected, abnormal left ventricular function during exercise.
A S Iskandrian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Herz     Volume:  13     ISSN:  0340-9937     ISO Abbreviation:  Herz     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-14     Completed Date:  1988-11-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
Philadelphia Heart Institute, Presbyterian-University of Pennsylvania Medical Center, Philadelphia.
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MeSH Terms
Arrhythmias, Cardiac / physiopathology
Cardiac Output
Coronary Disease / physiopathology
Exercise Test*
Heart Ventricles / physiopathology
Middle Aged
Mitral Valve / physiopathology
Mitral Valve Prolapse / physiopathology*

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