| Exercise intolerance in mitochondrial myopathy is not related to lactic acidosis. | |
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MedLine Citation:
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PMID: 11357960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a double-blinded, placebo-controlled, crossover study in seven mitochondrial myopathy patients (MM), we investigated whether lowering of lactate with dichloroacetate (DCA) can improve exercise tolerance and oxidative capacity in MM. DCA lowered plasma lactate at rest and during exercise (from 10.5 +/- 2.0 to 5.0 +/- 1.6 mM; p = 0.005) but did not improve maximal work load or VO2 in cycle exercise or phosphorous magnetic resonance spectroscopy (31P-MRS)-assessed indices of muscle oxidative metabolism. This indicates that lactate acidosis is not the primary cause of exercise intolerance in MM. |
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Authors:
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J Vissing; U Gansted; B Quistorff |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 49 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-18 Completed Date: 2001-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 672-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, National University Hospital, Rigshospitalet, Copenhagen, Denmark. vissing@rh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Lactic
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physiopathology* Adolescent Adult Double-Blind Method Ergometry Exercise Tolerance / physiology* Female Humans Magnetic Resonance Spectroscopy Male Middle Aged Mitochondrial Myopathies / metabolism, physiopathology* Muscles / metabolism, physiopathology* Questionnaires |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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