Document Detail

Exercise intolerance in mitochondrial myopathy is not related to lactic acidosis.
MedLine Citation:
PMID:  11357960     Owner:  NLM     Status:  MEDLINE    
In a double-blinded, placebo-controlled, crossover study in seven mitochondrial myopathy patients (MM), we investigated whether lowering of lactate with dichloroacetate (DCA) can improve exercise tolerance and oxidative capacity in MM. DCA lowered plasma lactate at rest and during exercise (from 10.5 +/- 2.0 to 5.0 +/- 1.6 mM; p = 0.005) but did not improve maximal work load or VO2 in cycle exercise or phosphorous magnetic resonance spectroscopy (31P-MRS)-assessed indices of muscle oxidative metabolism. This indicates that lactate acidosis is not the primary cause of exercise intolerance in MM.
J Vissing; U Gansted; B Quistorff
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  49     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-18     Completed Date:  2001-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  672-6     Citation Subset:  IM    
Department of Neurology, National University Hospital, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Acidosis, Lactic / physiopathology*
Double-Blind Method
Exercise Tolerance / physiology*
Magnetic Resonance Spectroscopy
Middle Aged
Mitochondrial Myopathies / metabolism,  physiopathology*
Muscles / metabolism,  physiopathology*

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