| Exercise intolerance in chronic heart failure: mechanisms and therapies. Part II. | |
| | |
MedLine Citation:
|
PMID: 21217245 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Muscular fatigue and dyspnoea on exertion are among the most common symptoms in chronic heart failure; however their origin is still poorly understood. Several studies have shown that cardiac dysfunction alone cannot fully explain their origin, but the contribution of the multiorgan failure present in this syndrome must be highlighted. We aimed to summarize the existing evidence and the most controversial aspects of the complex interplay of different factors involved in the symptom generation. In the first part of the review, six key factors were revised (the heart, the lung, the skeletal muscle, the hormonal changes, the O2 delivery to the periphery, the endothelium). In this second part, the role of the excitatory reflexes and the cardiac cachexia are presented. Finally, potential therapeutic implications are discussed here. We believe that a better knowledge of the pathophysiology of this syndrome may contribute to the management of the patients and to the improvement in their stress tolerance and quality of life. |
| | |
Authors:
|
Massimo F Piepoli; Marco Guazzi; Giuseppe Boriani; Mariantonietta Cicoira; Ugo Corrà; Luciano Dalla Libera; Michele Emdin; Donato Mele; Claudio Passino; Giorgio Vescovo; Carlo Vigorito; Giovanni Villani; Piergiuseppe Agostoni; |
Related Documents
:
|
9562525 - Animal model for fragile x syndrome. 3953655 - Autism in fragile x females. 2300265 - Amyotrophic lateral sclerosis in a patient with fragile x syndrome. 7688265 - The protein product of the fragile x gene, fmr1, has characteristics of an rna-binding ... 21043025 - Clinical findings and treatment in 63 cows with haemorrhagic bowel syndrome. 12077535 - Poems syndrome revealed by multiple glomeruloid angiomas. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 17 ISSN: 1741-8275 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2011-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
|
Languages: eng Pagination: 643-8 Citation Subset: IM |
Affiliation:
|
Heart Failure Unit, Department of Cardiology, G da Saliceto Hospital, Piacenza, Emilia Romagna, Italy. m.piepoli@ausl.pc.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HIV genetic diversity between plasma and cerebrospinal fluid in patients with HIV encephalitis.
Next Document: Core competencies for cardiac rehabilitation/secondary prevention professionals: 2010 update: positi...