Document Detail


Exercise induces two types of human luteal dysfunction: confirmation by urinary free progesterone.
MedLine Citation:
PMID:  1902847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously reported that during 2 months of strenuous exercise, untrained young women with documented ovulatory menstrual cycles developed secondary oligoamenorrhea and luteal phase defects. In this study we tested the hypothesis that such abnormalities arise by altered neuroendocrine regulation of menstrual hormone secretion and that weight loss potentiates such effects. We supply a detailed analysis of the 20 cycles, of the total of 53, in which luteal phase abnormalities occurred. During the control month and 2 exercise months, all subjects collected daily overnight urine samples for the determination of LH, FSH, estriol (E3), and free progesterone (P) excretion by RIAs and creatinine by chemical assay. The characteristics of the abnormal luteal phase cycles were determined by comparing the excreted hormone levels and patterns during the control cycles with those of exercise cycles. The area under the curve (AUC) for each hormone was calculated for the follicular and luteal phases of each cycle. Six of the exercise cycles exhibited an inadequate luteal phase. This was characterized by a mean integrated P area of 202.4 (SEM, -61.8) nmol/day.nmol creatinine, compared with 331.7 (SEM, 64.7) during the corresponding control cycles, over a period of 9 or more days after the urinary LH peak to the onset of menses. Fourteen of the exercise cycles exhibited a short luteal phase. This was characterized by a mean integrated P area of 75.9 (30.9) nmol/day.nmol creatinine, compared to 267 (61.7) during the corresponding control cycles, over a span of 8 days or less from the urinary LH peak to the onset of menses. Additional abnormalities occurred only in the short luteal phase cycles. These included an increase in the length and AUC for E3 of the follicular phase and a decrease in the AUC of LH during the luteal phase. We conclude that the initiation of strenuous endurance training in previously ovulating untrained women frequently leads to corpus luteum dysfunction associated with insufficient P secretion and, in the case of short luteal phase cycles, decreased luteal phase length. That exercise may alter the neuroendocrine system is suggested by a delay in the ovulatory LH peak in spite of increased E3 excretion; moreover, less LH is excreted during the luteal phase. The lack of positive feedback to estrogens and decreased LH secretion during the luteal phase could compromise corpus luteum function. In contrast, decreased free P excretion was the sole abnormality noted in menstrual cycles with an inadequate luteal phase.
Authors:
I Z Beitins; J W McArthur; B A Turnbull; G S Skrinar; B A Bullen
Related Documents :
2493897 - Short term effect of captopril on microalbuminuria induced by exercise in normotensive ...
22882137 - Facilitation of quadriceps activation is impaired following eccentric exercise.
18050057 - Discrimination of recombinant and endogenous urinary erythropoietin by calculating rela...
22765227 - Fatigue during intermittent-sprint exercise.
8695467 - Cardiology. exercise: a review.
9657057 - Effect of guarana on exercise in normal and epinephrine-induced glycogenolytic mice.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  72     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-06-13     Completed Date:  1991-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1350-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Michigan, Ann Arbor 48109.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Estriol / urine
Exercise*
Female
Follicle Stimulating Hormone / urine
Follicular Phase
Gonadal Steroid Hormones / urine
Gonadotropins / urine
Humans
Luteal Phase*
Luteinizing Hormone / metabolism,  urine
Menstrual Cycle / urine
Menstruation Disturbances / etiology*,  urine
Progesterone / blood*
Time Factors
Grant Support
ID/Acronym/Agency:
HD-18515/HD/NICHD NIH HHS; HD-18999/HD/NICHD NIH HHS; RR-1066/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Gonadotropins; 50-27-1/Estriol; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of recombinant human interleukin-2 and tumor necrosis factor-alpha with or without interfero...
Next Document:  Synaptic organization of columnar elements in the lamina of the wild type in Drosophila melanogaster...