Document Detail

Exercise induces mitochondrial biogenesis after brain ischemia in rats.
MedLine Citation:
PMID:  22266265     Owner:  NLM     Status:  Publisher    
Stroke is a major cause of death worldwide. Previous studies have suggested both exercise and mitochondrial biogenesis contribute to improved post-ischemic recovery of brain function. However, the exact mechanism underlying this effect is unclear. On the other hand, the benefit of exercise-induced mitochondrial biogenesis in brain has been confirmed. In this study, we attempted to determine whether treadmill exercise induces functional improvement through regulation of mitochondrial biogenesis after brain ischemia. We subjected adult male rats to ischemia, followed by either treadmill exercise or non-exercise and analyzed the effect of exercise on the amount of mitochondrial DNA (mtDNA), expression of mitochondrial biogenesis factors, and mitochondrial protein. In the ischemia-exercise group, only peroxisome proliferator activated receptor coactivator-1 (PGC-1) expression was increased significantly after 3 days of treadmill training. However, after 7 days of training, the levels of mtDNA, nuclear respiratory factor 1, NRF-1, mitochondrial transcription factor A, TFAM, and the mitochondrial protein cytochrome C oxidase subunit IV (COXIV) and heat shock protein-60 (HSP60) also increased above levels observed in non-exercised ischemic animals. These changes followed with significant changes in behavioral scores and cerebral infarct volume. The results indicate that exercise can promote mitochondrial biogenesis after ischemic injury, which may serve as a novel component of exercise-induced repair mechanisms of the brain. Understanding the molecular basis for exercise-induced neuroprotection may be beneficial in the development of therapeutic approaches for brain recovery from the ischemic injury. Based upon our findings, stimulation or enhancement of mitochondrial biogenesis may prove a novel neuroprotective strategy in the future.
Q Zhang; Y Wu; P Zhang; H Sha; J Jia; Y Hu; J Zhu
Related Documents :
15619135 - Pharmacokinetics of intravenous n-acetylcysteine in men at rest and during exercise.
3679645 - Metabolic changes during volleyball matches.
10052665 - Effect of repeated bouts of short-term exercise on plasma free and sulphoconjugated cat...
477215 - Effect of the exercise of seven consecutive days hill-walking on fluid homeostasis.
7713815 - Relationship between atrial natriuretic peptide and plasma volume during graded exercis...
7446075 - Computer-aided rhinometry. a research rhinometer for clinical trial.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-8
Journal Detail:
Title:  Neuroscience     Volume:  -     ISSN:  1873-7544     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Sports Medicine and Rehabilitation, Medical College of Fudan University, Shanghai 200032, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Osteoarthritis year 2011 in review: clinical.
Next Document:  The participation of plasma membrane hemichannels to purinergic signaling.