| Exercise induces an increase in muscle UCP3 as a component of the increase in mitochondrial biogenesis. | |
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MedLine Citation:
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PMID: 12388129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have indicated that exercise acutely induces large increases in uncoupling protein-3 (UCP3) in skeletal muscle, whereas endurance training results in marked decreases in muscle UCP3. Because UCP3 expression appears to be regulated by the same mechanism as other mitochondrial constituents, it seemed unlikely that exercise would result in such large and divergent changes in mitochondrial composition. The purpose of this study was to test the hypothesis that major changes in UCP3 protein concentration do not occur independently of mitochondrial biogenesis and that UCP3 increases as a component of the exercise-induced increase in mitochondria. We found a large increase in UCP3 mRNA immediately and 3 h after a bout of swimming. UCP3 protein concentration was increased approximately 35% 18 h after a single exercise bout, approximately 63% after 3 days, and approximately 84% after 10 days of exercise. These increases in UCP3 roughly paralleled those of other mitochondrial marker proteins. Our results are consistent with the interpretation that endurance exercise induces an adaptive increase in mitochondria that have a normal content of UCP3. |
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Authors:
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Terry E Jones; Keith Baar; Edward Ojuka; May Chen; John O Holloszy |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2002-09-17 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 284 ISSN: 0193-1849 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-17 Completed Date: 2003-01-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E96-101 Citation Subset: IM |
Affiliation:
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Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / genetics, metabolism* Ion Channels Male Mitochondria, Muscle / metabolism* Mitochondrial Proteins Muscle Fibers, Fast-Twitch / metabolism, ultrastructure Muscle Fibers, Slow-Twitch / metabolism, ultrastructure Muscle, Skeletal / metabolism*, ultrastructure Physical Conditioning, Animal Physical Exertion / physiology* RNA, Messenger / analysis Rats Rats, Wistar Swimming |
| Grant Support | |
ID/Acronym/Agency:
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AG-00078/AG/NIA NIH HHS; AG-00425/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Ion Channels; 0/Mitochondrial Proteins; 0/RNA, Messenger; 0/mitochondrial uncoupling protein 3 |
| Comments/Corrections | |
Comment In:
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Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E449-50; author reply 450-1
[PMID:
12531748
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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