Document Detail


Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue.
MedLine Citation:
PMID:  7864098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein lipase (LPL) is regulated by exercise in humans, but the effects of exercise on LPL expression in different tissues and the molecular mechanisms involved are unclear. We assessed the effects of 5-13 consecutive days of supervised exercise on tissue LPL expression as well as fasting plasma lipids and lipoproteins in 32 sedentary, weight-stable adult men. In skeletal muscle, exercise training increased the mean LPL mRNA level by 117% (P = 0.037), LPL protein mass by 53% (P = 0.038), and total LPL enzyme activity by 35% (P = 0.025). In adipose tissue, mean LPL mRNA, protein mass, and activity did not change. Exercise decreased triglycerides [from 172 +/- 4.3 to 127 +/- 3.2 (SE) mg/dl, P = 0.002], total cholesterol (from 188 +/- 1.2 to 181 +/- 1.0 mg/dl, P = 0.011), and very low-density lipoprotein-cholesterol (from 30.1 +/- 0.9 to 22.0 +/- 0.8, P = 0.004) and increased high-density lipoprotein cholesterol (HDL-C; from 43.4 +/- 0.35 to 45.0 +/- 0.37, P = 0.030) and HDL2-C (from 6.6 +/- 0.21 to 7.7 +/- 0.19, P = 0.021). Changes in muscle but not adipose tissue heparin-releasable LPL activity were inversely correlated (r = -0.435, P < 0.034) with changes in triglycerides. These data suggest the existence of an exercise stimulus intrinsic to skeletal muscle, which raises LPL activity in part by pretranslational mechanisms, a process that contributes to the improvement in circulating lipids seen with physical activity.
Authors:
R L Seip; T J Angelopoulos; C F Semenkovich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-21     Completed Date:  1995-03-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E229-36     Citation Subset:  IM; S    
Affiliation:
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / physiology*
Adult
Aged
Cholesterol, HDL / blood
Gene Expression*
Humans
Lipids / blood
Lipoprotein Lipase / genetics*,  metabolism
Lipoproteins / blood
Male
Middle Aged
Muscle, Skeletal / physiology*
Physical Exertion*
RNA, Messenger / metabolism
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
1F32HL-08409/HL/NHLBI NIH HHS; AG-05562/AG/NIA NIH HHS; HL-47436/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Lipids; 0/Lipoproteins; 0/RNA, Messenger; 0/Triglycerides; EC 3.1.1.34/Lipoprotein Lipase

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