| Exercise induces gastric ischemia in healthy volunteers: a tonometry study. | |
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MedLine Citation:
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PMID: 11457804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heavy physical exercise may cause gastrointestinal signs and symptoms, and, although splanchnic blood flow may decrease through redistribution by more than 50%, it is unclear whether these signs and symptoms relate to gastrointestinal ischemia. In 10 healthy volunteers, we studied the effect of exercise on gastric mucosal perfusion adequacy using air tonometry. Two relatively short (10 min) exercise stages were conducted on a cycle ergometer, aiming for 80 and 100% of maximum heart rate, respectively. The intragastric-arterial PCO(2) gradient (Delta PCO(2)) was elevated by 1.1 +/- 1.0 kPa over baseline values (-0.1 +/- 0.3 kPa) only after maximal exercise (P < 0.001). Delta PCO(2) positively correlated with the arterial lactate level taken as an index of exercise intensity (Spearman's rank test: r = 0.76, P < 0.0001). By bilinear regression analysis, a lactate level of 12 mmol/l, above which a sharp rise in the Delta PCO(2) occurred, was calculated. We conclude that, in healthy volunteers with normal splanchnic vasculature, gastric ischemia may develop during maximal exercise as judged from intragastric PCO(2) tonometry. |
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Authors:
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J A Otte; E Oostveen; R H Geelkerken; A B Groeneveld; J J Kolkman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 91 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-07-17 Completed Date: 2001-09-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 866-71 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Gastroenterology, Medisch Spectrum Twente, Enschede, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Dioxide / blood, metabolism Exercise / physiology* Female Gastric Mucosa / blood supply* Heart Rate Humans Ischemia* Lactates / blood Male Manometry / methods Partial Pressure Physical Exertion / physiology* Reference Values Regression Analysis Respiratory Mechanics / physiology Rest Splanchnic Circulation Stomach / blood supply* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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