Document Detail


Exercise induces gastric ischemia in healthy volunteers: a tonometry study.
MedLine Citation:
PMID:  11457804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heavy physical exercise may cause gastrointestinal signs and symptoms, and, although splanchnic blood flow may decrease through redistribution by more than 50%, it is unclear whether these signs and symptoms relate to gastrointestinal ischemia. In 10 healthy volunteers, we studied the effect of exercise on gastric mucosal perfusion adequacy using air tonometry. Two relatively short (10 min) exercise stages were conducted on a cycle ergometer, aiming for 80 and 100% of maximum heart rate, respectively. The intragastric-arterial PCO(2) gradient (Delta PCO(2)) was elevated by 1.1 +/- 1.0 kPa over baseline values (-0.1 +/- 0.3 kPa) only after maximal exercise (P < 0.001). Delta PCO(2) positively correlated with the arterial lactate level taken as an index of exercise intensity (Spearman's rank test: r = 0.76, P < 0.0001). By bilinear regression analysis, a lactate level of 12 mmol/l, above which a sharp rise in the Delta PCO(2) occurred, was calculated. We conclude that, in healthy volunteers with normal splanchnic vasculature, gastric ischemia may develop during maximal exercise as judged from intragastric PCO(2) tonometry.
Authors:
J A Otte; E Oostveen; R H Geelkerken; A B Groeneveld; J J Kolkman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  91     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-17     Completed Date:  2001-09-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  866-71     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Gastroenterology, Medisch Spectrum Twente, Enschede, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbon Dioxide / blood,  metabolism
Exercise / physiology*
Female
Gastric Mucosa / blood supply*
Heart Rate
Humans
Ischemia*
Lactates / blood
Male
Manometry / methods
Partial Pressure
Physical Exertion / physiology*
Reference Values
Regression Analysis
Respiratory Mechanics / physiology
Rest
Splanchnic Circulation
Stomach / blood supply*
Time Factors
Chemical
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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