Document Detail

Exercise induces a change in plasma fibrinogen concentration: fact or fiction?
MedLine Citation:
PMID:  10632470     Owner:  NLM     Status:  MEDLINE    
This study examined the effect of exercise on plasma fibrinogen concentrations with simultaneous measurements of plasma volume changes. Eight moderately active males aged 26.6+/-3.6 years (mean +/- SD) completed maximal (VO2max) and submaximal (75% VO2max for 30 minutes) exercise trials separated by 7 days. Venous blood samples were obtained at rest, immediately postexercise, and following 30 minutes of recovery. Whole blood was analysed for haematocrit and haemoglobin, while citrated plasma was assayed for fibrinogen levels. Values of haematocrit and haemoglobin before and after exercise were utilised for the estimation of plasma volume changes. Plasma volume decreased (p<0.05) immediately following both maximal (-17.7+/-5.1%) and submaximal (-14.3+/-4.1%) exercise. Exercise resulted in decreased plasma fibrinogen levels (maximal exercise: from 266.3+/-14.5 to 222.2+/-23.9 mg x dL(-1); submaximal exercise: from 239.5+/-45.4 to 209.7+/-42.4 mg x dL(-1)) only when postexercise raw data were corrected for the contraction of plasma volume. It is concluded therefore that changes in plasma volume in response to exercise should be taken into account when interpreting exercise effects on plasma fibrinogen concentration.
M S El-Sayed; P G Jones; C Sale
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  96     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-27     Completed Date:  2000-01-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, England.
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MeSH Terms
Analysis of Variance
Exercise / physiology*
Fibrinogen / metabolism*
Physical Exertion / physiology*
Plasma Volume / physiology*
Reference Values
Time Factors
Reg. No./Substance:

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