| Exercise induces biventricular mechanical dyssynchrony in children with repaired tetralogy of Fallot. | |
| | |
MedLine Citation:
|
PMID: 21088123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The mechanisms underlying adverse electro-mechanical interaction after tetralogy of Fallot (TOF) repair remain unclear. This study investigated biventricular dyssynchrony in children with TOF and its relationship to exercise, QRS duration (QRSd) and ventricular mechanics. METHODS: 29 asymptomatic children (5-18 years) with repaired TOF were prospectively evaluated by MRI, cardiopulmonary exercise testing and echocardiography at rest and during bicycle exertion. Their dyssynchrony results were compared with those of 44 resting and 27 exercising, age- and sex-matched controls. An intraventricular dyssynchrony index was calculated from the SD of regional time intervals in 12 left ventricular (LV) 'Ts LV-12SD' and eight right ventricular (RV) 'Ts RV-8SD' segments. Ventricular size, volumes, ejection fractions, pulmonary regurgitant volumes and peak oxygen consumption and N-terminal BNP levels were quantified in the patients. RESULTS: Despite moderate RV dilatation (median indexed RV end-diastolic volume 145.2 ml/m(2)) and right bundle branch block (median QRSd 130 ms) compared with controls, children with TOF demonstrated neither RV nor LV dyssynchrony at rest (Ts RV-8SD, 37.9±10.2 vs 44.3±10.3, 95% CI -11.8 to -0.99, p=0.02; Ts LV-12SD, 38.6±16.8 vs 34.0±10.8, 95% CI -1.8 to 11.0, p=0.16). Exercise stress induced biventricular dyssynchrony in patients with TOF but not in controls (Ts RV-8SD, 59.9±34.4 vs 28.2±10.4, p<0.0001, 95% CI 17.2 to 46.3; Ts LV-12SD, 48.0±18.6 vs 31.9±10.7, 95% CI 7.9 to 24.4, p=0.002). This was unrelated to QRSd, ventricular volumes and function, or peak oxygen consumption. CONCLUSION: Exercise induces biventricular mechanical dyssynchrony in children with TOF. |
| | |
Authors:
|
S Lucy Roche; Lars Grosse-Wortmann; Andrew N Redington; Cameron Slorach; Gareth Smith; Paul F Kantor; Mark K Friedberg |
Related Documents
:
|
18728093 - Computer-based exercises for learning to read and spell by deaf children. 8236363 - Audit of theophylline plasma level monitoring in a pediatric hospital. 3256623 - Brain transections demonstrate the central origin of hypoxic ventilatory depression in ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 96 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-22 Completed Date: 2011-01-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
|
Languages: eng Pagination: 2010-5 Citation Subset: AIM; IM |
Affiliation:
|
The Labatt Family Heart Center, The Hospital for Sick Children, Toronto, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Arrhythmias, Cardiac / etiology* Child Child, Preschool Echocardiography Exercise / physiology* Female Humans Magnetic Resonance Angiography Male Prospective Studies Pulmonary Valve Insufficiency / etiology Tetralogy of Fallot / complications*, surgery Ventricular Dysfunction, Left / etiology* Ventricular Dysfunction, Right / etiology* |
| Grant Support | |
ID/Acronym/Agency:
|
//Canadian Institutes of Health Research |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Echocardiographic assessment of raised pulmonary vascular resistance: application to diagnosis and f...
Next Document: Microbiological and immunological effects of enteral feeding on the upper gastrointestinal tract.