Document Detail


Exercise induces BDNF and synapsin I to specific hippocampal subfields.
MedLine Citation:
PMID:  15079864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the relationship between brain-derived neurotrophic factor (BDNF) and synapsin I in the hippocampus during exercise, we employed a novel microsphere injection method to block the action of BDNF through its tyrosine kinase (Trk) receptor and subsequently measure the mRNA levels of synapsin I, using real-time TaqMan RT-PCR for RNA quantification. After establishing a causal link between BDNF and exercise-induced synapsin I mRNA levels, we studied the exercise-induced distribution of BDNF and synapsin I in the rodent hippocampus. Quantitative immunohistochemical analysis revealed increases of BDNF and synapsin I in CA3 stratum lucidum and dentate gyrus, and synapsin I alone in CA1 stratum radiatum and stratum laconosum moleculare. These results indicate that exercise induces plasticity of select hippocampal transsynaptic circuitry, possibly comprising a spatial restriction on synapsin I regulation by BDNF.
Authors:
Shoshanna Vaynman; Zhe Ying; Fernando Gómez-Pinilla
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  76     ISSN:  0360-4012     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-13     Completed Date:  2004-07-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  356-62     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Affiliation:
Department of Physiological Science, UCLA, Los Angeles, California 90095, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain-Derived Neurotrophic Factor / metabolism*
Carbazoles / administration & dosage
Enzyme Inhibitors / administration & dosage
Hippocampus / enzymology,  metabolism*
Indole Alkaloids
Male
Microspheres
Neuronal Plasticity / physiology
Physical Conditioning, Animal / physiology*
Protein Kinase C / antagonists & inhibitors
Random Allocation
Rats
Rats, Sprague-Dawley
Receptor, trkB / antagonists & inhibitors,  metabolism
Signal Transduction / physiology
Synapsins / metabolism*
Grant Support
ID/Acronym/Agency:
NS 38978/NS/NINDS NIH HHS; NS 39522/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Carbazoles; 0/Enzyme Inhibitors; 0/Indole Alkaloids; 0/Synapsins; 97161-97-2/K 252; EC 2.7.10.1/Receptor, trkB; EC 2.7.11.13/Protein Kinase C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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