| Exercise-induced vasodilation is associated with menopause stage in healthy middle-aged women. | |
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MedLine Citation:
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PMID: 22486379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leg exercise hemodynamics during single-leg knee extensions were compared among healthy groups of early perimenopausal (n = 15), late perimenopausal (n = 12), and early postmenopausal (n = 11) women. Femoral blood flow (FBF) and vascular conductance (FVC) at rest and during very light work rates (0 and 5 W) were similar among all three menopause stage groups. Vascular responses at 10 W (FBF) and 20 W (FBF and FVC) were significantly higher (P < 0.05) in early perimenopausal compared with late perimenopausal women. At 15 and 25 W, FBF and FVC were similar between late perimenopausal and early postmenopausal groups but higher (P < 0.05) in early perimenopausal women as compared with the other two menopausal groups. In the combined sample of all three menopause stage groups, follicle-stimulating hormone was significantly correlated with vascular conductance during submaximal (15 W) exercise (R = -0.56, P < 0.001), even after adjustment for age, fitness, LDL cholesterol, and abdominal fat (R = -0.46, P = 0.005). Collectively, these findings suggest that in middle-aged women, there is an association between menopause stage and leg vascular responsiveness during exercise. |
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Authors:
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David J Moore; Joaquin U Gonzales; Steven H Tucker; Steriani Elavsky; David N Proctor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-04-10 |
Journal Detail:
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Title: Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme Volume: 37 ISSN: 1715-5312 ISO Abbreviation: Appl Physiol Nutr Metab Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-03 Completed Date: 2012-07-26 Revised Date: 2013-04-12 |
Medline Journal Info:
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Nlm Unique ID: 101264333 Medline TA: Appl Physiol Nutr Metab Country: Canada |
Other Details:
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Languages: eng Pagination: 418-24 Citation Subset: IM |
Affiliation:
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Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Blood Flow Velocity Blood Pressure / physiology Estradiol / blood Exercise / physiology* Exercise Test / methods Female Femoral Artery / physiology, ultrasonography Follicle Stimulating Hormone / blood Heart Rate / physiology Humans Hyperemia / blood Knee Joint / physiology Leg / blood supply, physiology Menopause / blood* Middle Aged Muscle Contraction / physiology Reference Values Regional Blood Flow Ultrasonography, Doppler Vasodilation / physiology* Women's Health |
| Grant Support | |
ID/Acronym/Agency:
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K12 HD055882/HD/NICHD NIH HHS; M01 RR-10732/RR/NCRR NIH HHS; M01 RR010732/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 9002-68-0/Follicle Stimulating Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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