Document Detail

Exercise-induced vasodilation is associated with menopause stage in healthy middle-aged women.
MedLine Citation:
PMID:  22486379     Owner:  NLM     Status:  MEDLINE    
Leg exercise hemodynamics during single-leg knee extensions were compared among healthy groups of early perimenopausal (n = 15), late perimenopausal (n = 12), and early postmenopausal (n = 11) women. Femoral blood flow (FBF) and vascular conductance (FVC) at rest and during very light work rates (0 and 5 W) were similar among all three menopause stage groups. Vascular responses at 10 W (FBF) and 20 W (FBF and FVC) were significantly higher (P < 0.05) in early perimenopausal compared with late perimenopausal women. At 15 and 25 W, FBF and FVC were similar between late perimenopausal and early postmenopausal groups but higher (P < 0.05) in early perimenopausal women as compared with the other two menopausal groups. In the combined sample of all three menopause stage groups, follicle-stimulating hormone was significantly correlated with vascular conductance during submaximal (15 W) exercise (R = -0.56, P < 0.001), even after adjustment for age, fitness, LDL cholesterol, and abdominal fat (R = -0.46, P = 0.005). Collectively, these findings suggest that in middle-aged women, there is an association between menopause stage and leg vascular responsiveness during exercise.
David J Moore; Joaquin U Gonzales; Steven H Tucker; Steriani Elavsky; David N Proctor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-10
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  37     ISSN:  1715-5312     ISO Abbreviation:  Appl Physiol Nutr Metab     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-03     Completed Date:  2012-07-26     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  418-24     Citation Subset:  IM    
Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA.
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MeSH Terms
Analysis of Variance
Blood Flow Velocity
Blood Pressure / physiology
Estradiol / blood
Exercise / physiology*
Exercise Test / methods
Femoral Artery / physiology,  ultrasonography
Follicle Stimulating Hormone / blood
Heart Rate / physiology
Hyperemia / blood
Knee Joint / physiology
Leg / blood supply,  physiology
Menopause / blood*
Middle Aged
Muscle Contraction / physiology
Reference Values
Regional Blood Flow
Ultrasonography, Doppler
Vasodilation / physiology*
Women's Health
Grant Support
Reg. No./Substance:
50-28-2/Estradiol; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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