Document Detail


Exercise-induced stress resistance is independent of exercise controllability and the medial prefrontal cortex.
MedLine Citation:
PMID:  23121339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise increases resistance against stress-related disorders such as anxiety and depression. Similarly, the perception of control is a powerful predictor of neurochemical and behavioral responses to stress, but whether the experience of choosing to exercise, and exerting control over that exercise, is a critical factor in producing exercise-induced stress resistance is unknown. The current studies investigated whether the protective effects of exercise against the anxiety- and depression-like consequences of stress are dependent on exercise controllability and a brain region implicated in the protective effects of controllable experiences, the medial prefrontal cortex. Adult male Fischer 344 rats remained sedentary, were forced to run on treadmills or motorised running wheels, or had voluntary access to wheels for 6 weeks. Three weeks after exercise onset, rats received sham surgery or excitotoxic lesions of the medial prefrontal cortex. Rats were exposed to home cage or uncontrollable tail shock treatment three weeks later. Shock-elicited fear conditioning and shuttle box escape testing occurred the next day. Both forced and voluntary wheel running, but not treadmill training, prevented the exaggerated fear conditioning and interference with escape learning produced by uncontrollable stress. Lesions of the medial prefrontal cortex failed to eliminate the protective effects of forced or voluntary wheel running. These data suggest that exercise controllability and the medial prefrontal cortex are not critical factors in conferring the protective effects of exercise against the affective consequences of stressor exposure, and imply that exercise perceived as forced may still benefit affect and mental health.
Authors:
Benjamin N Greenwood; Katie G Spence; Danielle M Crevling; Peter J Clark; Wendy C Craig; Monika Fleshner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-04
Journal Detail:
Title:  The European journal of neuroscience     Volume:  37     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-15     Revised Date:  2013-12-16    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  469-78     Citation Subset:  IM    
Copyright Information:
© 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / physiopathology
Conditioning, Classical
Depressive Disorder / physiopathology
Electroshock
Male
Physical Exertion*
Prefrontal Cortex / physiopathology*
Rats
Rats, Inbred F344
Stress, Physiological*
Stress, Psychological / physiopathology*
Grant Support
ID/Acronym/Agency:
R01 MH068283/MH/NIMH NIH HHS; R01-MH068283/MH/NIMH NIH HHS; R03-MH086665/MH/NIMH NIH HHS

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