| Exercise-induced stress inhibits both the induction and elicitation phases of in vivo T-cell-mediated immune responses in humans. | |
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MedLine Citation:
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PMID: 21362469 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Little is known about the influence of exercise on induction and elicitation phases of in-vivo immunity in humans. We used experimental contact-hypersensitivity, a clinically relevant in-vivo measure of T cell-mediated immunity, to investigate the effects of exercise on induction and elicitation phases of immune responses to a novel antigen. The effects of 2h-moderate-intensity-exercise upon the induction (Study One) and elicitation of in-vivo immune memory (Study Two) to diphenylcyclopropenone (DPCP) were examined. Study One: Matched, healthy males were randomly-assigned to exercise (N=16) or control (N=16) and received a primary DPCP exposure (sensitization), 20min after either 2h running at 60% V. O(2peak) (EX) or 2h seated rest (CON). Four weeks later, participants received a low, dose-series DPCP challenge (elicitation) on their upper inner arm, which was read at 24 and 48h as clinical score, oedema (skinfold thickness) and redness (erythema). Study Two: Pilot; Thirteen healthy males were sensitized to DPCP. Elicitation challenges were repeated every four weeks until responses reached a reproducible plateau. Then, N=9 from the pilot study completed both EX and CON trials in a randomized order. Elicitation challenges were applied and evaluated as in Study One. Results demonstrate that exercise-induced stress significantly impairs both the induction (oedema -53% at 48h; P<0.001) and elicitation (oedema -19% at 48h; P<0.05) phases of the in-vivo T-cell-mediated immune response. These findings demonstrate that prolonged moderate-intensity exercise impairs the induction and elicitation phases of in-vivo T-cell-mediated immunity. Moreover, the induction component of new immune responses appears more sensitive to systemic-stress-induced modulation than the elicitation component. |
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Authors:
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Adam D Harper Smith; Sarah L Coakley; Mark D Ward; Andrew W Macfarlane; Peter S Friedmann; Neil P Walsh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-26 |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: - ISSN: 1090-2139 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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College of Health and Behavioural Sciences, Bangor University, Bangor, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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