Document Detail


Exercise-induced stress inhibits both the induction and elicitation phases of in vivo T-cell-mediated immune responses in humans.
MedLine Citation:
PMID:  21362469     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Little is known about the influence of exercise on induction and elicitation phases of in-vivo immunity in humans. We used experimental contact-hypersensitivity, a clinically relevant in-vivo measure of T cell-mediated immunity, to investigate the effects of exercise on induction and elicitation phases of immune responses to a novel antigen. The effects of 2h-moderate-intensity-exercise upon the induction (Study One) and elicitation of in-vivo immune memory (Study Two) to diphenylcyclopropenone (DPCP) were examined. Study One: Matched, healthy males were randomly-assigned to exercise (N=16) or control (N=16) and received a primary DPCP exposure (sensitization), 20min after either 2h running at 60% V. O(2peak) (EX) or 2h seated rest (CON). Four weeks later, participants received a low, dose-series DPCP challenge (elicitation) on their upper inner arm, which was read at 24 and 48h as clinical score, oedema (skinfold thickness) and redness (erythema). Study Two: Pilot; Thirteen healthy males were sensitized to DPCP. Elicitation challenges were repeated every four weeks until responses reached a reproducible plateau. Then, N=9 from the pilot study completed both EX and CON trials in a randomized order. Elicitation challenges were applied and evaluated as in Study One. Results demonstrate that exercise-induced stress significantly impairs both the induction (oedema -53% at 48h; P<0.001) and elicitation (oedema -19% at 48h; P<0.05) phases of the in-vivo T-cell-mediated immune response. These findings demonstrate that prolonged moderate-intensity exercise impairs the induction and elicitation phases of in-vivo T-cell-mediated immunity. Moreover, the induction component of new immune responses appears more sensitive to systemic-stress-induced modulation than the elicitation component.
Authors:
Adam D Harper Smith; Sarah L Coakley; Mark D Ward; Andrew W Macfarlane; Peter S Friedmann; Neil P Walsh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-26
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  -     ISSN:  1090-2139     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
College of Health and Behavioural Sciences, Bangor University, Bangor, UK.
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