Document Detail

Exercise-induced rise in arterial potassium is enhanced in patients with impaired exercise tolerance.
MedLine Citation:
PMID:  7760513     Owner:  NLM     Status:  MEDLINE    
We assessed the changes in arterial potassium concentration during exercise and recovery in relation to exercise tolerance in patients with impaired exercise tolerance. Sixteen patients with cardiac disease were subjected to a cardiopulmonary exercise test on a cycle ergometer. Arterial potassium and lactate concentrations were measured every minute during and after exercise, and ventilatory threshold (VT) and lactate threshold (LT) were identified. Before exercise, arterial potassium concentration was 3.8 +/- 0.3 mEq/l. It increased to 4.1 +/- 0.3 mEq/l at LT (p < 0.002 versus at rest), to 4.2 +/- 0.3 mEq/l at VT, and to 4.8 +/- 0.5 mEq/l at peak exercise (p < 0.001 versus at LT, p < 0.001 versus at VT). At an exercise intensity equivalent to 30, 40, 50 or 60% of predicted maximum oxygen uptake, the increase in arterial potassium showed a negative and significant correlation with %LT (r = -0.62 approximately -0.72, p < 0.01 approximately 0.05) and %VT (r = -0.62 approximately -0.75, p < 0.001 approximately 0.05), where %LT and %VT represent the ratios of LT and VT to the predicted maximum oxygen uptake, respectively. There was a good correlation between the rate of fall in potassium concentration during recovery and its increase during exercise. It was concluded that in patients with impaired exercise tolerance, the greater the degree of exercise intolerance, the greater the increase in arterial potassium concentration during exercise, and the steeper the fall in potassium concentration during recovery. Because the rise in potassium concentration during exercise and its fall during recovery were greater when the exercise level exceeded the anaerobic threshold, exercise levels below the anaerobic threshold are recommended for patients with cardiac diseases.
S Watanabe; R Ajisaka; T Masuoka; T Yamanouchi; T Saito; M Toyama; N Takeyasu; K Sakamoto; Y Sugishita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  36     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-26     Completed Date:  1995-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  37-48     Citation Subset:  IM    
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
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MeSH Terms
Anaerobic Threshold
Exercise Test*
Exercise Tolerance*
Lactates / blood
Lactic Acid
Middle Aged
Myocardial Ischemia / blood,  physiopathology*
Oxygen Consumption
Potassium / blood*
Pulmonary Gas Exchange
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; 7440-09-7/Potassium

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