Document Detail


Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes.
MedLine Citation:
PMID:  22160404     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AimsEndurance training may be associated with arrhythmogenic cardiac remodelling of the right ventricle (RV). We examined whether myocardial dysfunction following intense endurance exercise affects the RV more than the left ventricle (LV) and whether cumulative exposure to endurance competition influences cardiac remodelling (including fibrosis) in well-trained athletes.Methods and resultsForty athletes were studied at baseline, immediately following an endurance race (3-11 h duration) and 1-week post-race. Evaluation included cardiac troponin (cTnI), B-type natriuretic peptide, and echocardiography [including three-dimensional volumes, ejection fraction (EF), and systolic strain rate]. Delayed gadolinium enhancement (DGE) on cardiac magnetic resonance imaging (CMR) was assessed as a marker of myocardial fibrosis. Relative to baseline, RV volumes increased and all functional measures decreased post-race, whereas LV volumes reduced and function was preserved. B-type natriuretic peptide (13.1 ± 14.0 vs. 25.4 ± 21.4 ng/L, P = 0.003) and cTnI (0.01 ± .03 vs. 0.14 ± .17 μg/L, P < 0.0001) increased post-race and correlated with reductions in RVEF (r = 0.52, P = 0.001 and r = 0.49, P = 0.002, respectively), but not LVEF. Right ventricular ejection fraction decreased with increasing race duration (r = -0.501, P < 0.0001) and VO(2)max (r = -0.359, P = 0.011). Right ventricular function mostly recovered by 1 week. On CMR, DGE localized to the interventricular septum was identified in 5 of 39 athletes who had greater cumulative exercise exposure and lower RVEF (47.1 ± 5.9 vs. 51.1 ± 3.7%, P = 0.042) than those with normal CMR.ConclusionIntense endurance exercise causes acute dysfunction of the RV, but not the LV. Although short-term recovery appears complete, chronic structural changes and reduced RV function are evident in some of the most practiced athletes, the long-term clinical significance of which warrants further study.
Authors:
André La Gerche; Andrew T Burns; Don J Mooney; Warrick J Inder; Andrew J Taylor; Jan Bogaert; Andrew I Macisaac; Hein Heidbüchel; David L Prior
Related Documents :
21611824 - Comparisons of local and systemic aerobic fitness parameters between finswimmers with d...
2654774 - The impact of food intake and exercise on energy expenditure.
21682864 - Cope-icd: a randomised clinical trial studying the effects and meaning of a comprehensi...
21059024 - Oxidative stress and antioxidant status in intensely exercising horses administered nut...
22676304 - Ventilatory efficiency testing as prognostic value in patients with pulmonary hypertens...
21448084 - Trunk muscle activity duringexercises performed on land and in water.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-6
Journal Detail:
Title:  European heart journal     Volume:  -     ISSN:  1522-9645     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Melbourne Department of Medicine, St Vincent's Hospital, 29 Regent Street, Fitzroy VIC 3065, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.
Next Document:  Use of microperimetry to compare macular light sensitivity in eyes with open-angle and angle-closure...