Document Detail


Exercise-induced pulmonary hemorrhage.
MedLine Citation:
PMID:  12747663     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
EIPH is a condition affecting virtually all horses during intense exercise worldwide. The hemorrhage originates from the pulmonary vasculature and is distributed predominantly bilaterally in the dorsocaudal lung lobes. As the condition progresses, the lung abnormalities extend cranially along the dorsal portions of the lung. An inflammatory response occurs in association with the hemorrhage and may contribute to the chronic sequela. Although conflicting opinions exist as to its affect on performance, it is a syndrome that is thought to increase in severity with age. The most commonly performed method to diagnose EIPH at the present time is endoscopy of the upper airway alone or in combination with tracheal wash analysis for the presence of erythrocytes and hemosiderophages. Because horses may not bleed to the same extent every time and the bleeding may originate from slightly different locations, these diagnostic procedures may not be extremely sensitive or quantitative. At this time, there is no treatment that is considered a panacea, and the currently allowed treatments have not proven to be effective in preventing EIPH. Future directions for therapeutic intervention may need to include limiting inflammatory responses to blood remaining within the lungs after EIPH.
Authors:
Eric K Birks; Mary M Durando; Steve McBride
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Veterinary clinics of North America. Equine practice     Volume:  19     ISSN:  0749-0739     ISO Abbreviation:  Vet. Clin. North Am. Equine Pract.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-15     Completed Date:  2003-07-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8511904     Medline TA:  Vet Clin North Am Equine Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-100     Citation Subset:  IM    
Affiliation:
Sports Medicine and Imaging, Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Road, Kennett Square, PA 19348-1692, USA. ebirks@vet.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Diuretics / therapeutic use
Furosemide / therapeutic use
Hemorrhage / diagnosis,  drug therapy,  etiology,  veterinary*
Horse Diseases / diagnosis,  drug therapy,  etiology*
Horses
Lung Diseases / diagnosis,  drug therapy,  etiology,  veterinary*
Physical Exertion*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Diuretics; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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