Document Detail

Exercise-induced pulmonary blood volume changes and diastolic dysfunction of the aged heart.
MedLine Citation:
PMID:  2714033     Owner:  NLM     Status:  MEDLINE    
Impaired diastolic function has been described in healthy elderly subjects. Pulmonary blood volume (PBV) changes with exercise have been associated with left ventricular dysfunction, but not directly related to diastolic abnormalities. Exercise-induced relative changes in PBV were measured using gated blood pool imaging with count density comparisons over the lung in 20 healthy volunteers: 13 elderly, age 76 +/- 5 years and seven young, age 27 +/- 4 years. Serial (first exercise stage, peak exercise, and post exercise) PBV ratios were measured and correlated to peak early filling rate, peak late filling rate, and percent atrial filling obtained from the resting left ventricular time-activity curve analysis. PBV ratios tended to be higher in elderly subjects, but reached significance only at the first stage of exercise (1.04 +/- 0.07 vs. 0.93 +/- 0.10, p less than 0.01). Significant correlations were found between PBV ratios at first exercise stage and peak early filling rate (r = -0.64), peak late filling rate (r = 0.47), and percent atrial filling (r = 0.48). A significant correlation was found between PBV changes at peak exercise and resting diastolic parameters. Exercise-induced PBV changes are associated with left ventricular diastolic dysfunction at rest. Diastolic abnormalities of the aged heart may explain the differential PBV response early into exercise between young and elderly healthy subjects.
D Alexopoulos; J Machac; R R Arora; S F Horowitz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical cardiology     Volume:  12     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-14     Completed Date:  1989-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Department of Medicine, Mount Sinai Medical Center, New York, New York 10029.
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MeSH Terms
Blood Pressure
Blood Volume*
Exercise Test*
Heart Rate
Myocardial Contraction*
Pulmonary Circulation*
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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