Document Detail

Exercise-induced plasticity of AMPA-type glutamate receptor subunits in the rat brain.
MedLine Citation:
PMID:  20869354     Owner:  NLM     Status:  In-Process    
The aim of this study was to analyze the plastic effects of moderate exercise upon the motor cortex (M1 and M2 areas), cerebellum (Cb), and striatum (CPu) of the rat brain. This assessment was made by verifying the expression of AMPA-type glutamate receptor subunits (GluR1 and GluR2/3). We used adult Wistar rats, divided into 5 groups based on duration of exercise training, namely 3 days (EX3), 7 days (EX7), 15 days (EX15), 30 days (EX30), and sedentary (S). The exercised animals were subjected to a treadmill exercise protocol at the speed of the 10 meters/min for 40 min. After exercise, the brains were subjected to immunohistochemistry and immunoblotting to analyze changes of GluR1 and GluR2/3, and plasma corticosterone was measured by ELISA in order to verify potential stress induced by physical training. Overall, the results of immunohistochemistry and immunoblotting were similar and revealed that GluR subunits show distinct responses over the exercise periods and for the different structures analyzed. In general, there was increased expression of GluR subunits after longer exercise periods (such as EX30), although some opposite effects were seen after short periods of exercise (EX3). In a few cases, biphasic patterns with decreases and subsequent increases of GluR expression were seen and may represent the outcome of exercise-dependent, complex regulatory processes. The data show that the protocol used was able to promote plastic GluR changes during exercise, suggesting a specific involvement of these receptors in exercise-induced plasticity processes in the brain areas tested.
Caroline C Real; Ana F B Ferreira; Marina S Hernandes; Luiz R G Britto; Raquel S Pires
Related Documents :
19618134 - The effects of exercise and zinc deficiency on some elements in rats.
19131214 - Beneficial effects of gradual intense exercise in tissues of rats fed with a diet defic...
23942244 - Oral estrogen therapy may mitigate the effects of aerobic training on cardiorespiratory...
9450504 - The effects of chronic exercise on metabolic and reproductive functions in male rats.
7817734 - Onset and duration of hypoalgesia following application of lidocaine spray on genital m...
2131784 - Oxygen radicals produce airway constriction and hyperresponsiveness in anesthetized cats.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-22
Journal Detail:
Title:  Brain research     Volume:  1363     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  63-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Laboratory of Cellular Neurobiology, Department of Physiology and Biophysics, University of São Paulo, São Paulo 05508-900, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Distribution of SV2C mRNA and protein expression in the mouse brain with a particular emphasis on th...
Next Document:  Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specifi...