Document Detail


Exercise-induced oxidative stress in overweight adolescent girls: roles of basal insulin resistance and inflammation and oxygen overconsumption.
MedLine Citation:
PMID:  19363498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HYPOTHESIS: Basal insulin resistance (IR) and inflammation exacerbate post-exercise oxidative stress (OS) in overweight adolescent girls. DESIGN: Cross-sectional study, effect of incremental ergocycle exercise until exhaustion on OS markers. PARTICIPANTS: Normal-weight (control) (n=17, body mass index (BMI): 20-24.2 kg/m(2)) and overweight adolescent girls (n=29, BMI: 24.1-36.6 kg/m(2)). MEASUREMENTS: Dietary measurement, physical activity assessment (validated questionnaires), fat distribution parameters (by dual-energy X-ray absorptiometry and anthropometry) and maximal oxygen consumption (VO2peak). Blood assays include the following: (1) at fasting state: blood cell count, lipid profile, and IR parameters (leptin/adiponectin ratio (L/A), homeostasis model assessment of IR, insulin/glucose ratio; (2) before exercise: inflammation and OS markers (interleukin-6 (IL-6), C-reactive protein (CRP), myeloperoxidase (MPO), reduced glutathione/oxidized glutathione ratio (GSH/GSSG), 15 F(2)alpha-isoprostanes (F(2)-Isop), lipid hydroperoxides (ROOH), oxidized low-density lipoprotein (ox-LDL)) and antioxidant status (superoxide dismutase (SOD), glutathione peroxidase (GPX), vitamin C, alpha-tocopherol and beta-carotene); and (3) after exercise: inflammation and OS markers. RESULTS: At rest, overweight girls had a deteriorated lipid profile and significantly higher values of IR parameters and inflammation markers, compared with the control girls. These alterations were associated with a moderate rest OS state (lower GSH/GSSG ratio, alpha-tocopherol/total cholesterol (TC) ratio and GPX activity). In absolute values, overweight girls exhibited higher peak power output and oxygen consumption (VO2peak), compared with the control girls. Exercise exacerbated OS only in the overweight group (significant increase in F(2)-Isop, ROOH and MPO). As hypothesized, basal IR and inflammation state were correlated with the post-exercise OS. However, the adjustment of F(2)-Isop, ROOH and MPO variation per exercise VO(2) variation canceled the intergroup differences. CONCLUSION: In overweight adolescent girls, the main factors of OS, after incremental exhaustive exercise, are not the basal IR and inflammation states, but oxygen overconsumption.
Authors:
H Youssef; C Groussard; J Pincemail; E Moussa; C Jacob; S Lemoine; M Zind; J-O Defraigne; J Cillard; P Delamarche; A Gratas-Delamarche
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  33     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2010-04-08     Revised Date:  2010-05-03    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  447-55     Citation Subset:  IM    
Affiliation:
Laboratory Mouvement Sport Sant? (EA1274), University of Rennes 2, ENS Cachan, UFR-APS, Rennes Cedex, France. hala.youssef@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anthropometry
Body Mass Index
Cross-Sectional Studies
Energy Metabolism
Exercise Test / methods
Female
Humans
Inflammation / metabolism
Insulin / analogs & derivatives*,  metabolism
Insulin Resistance*
Lebanon / epidemiology
Obesity / complications,  metabolism
Overweight / complications,  metabolism*
Oxidative Stress
Oxygen Consumption*
Young Adult
Chemical
Reg. No./Substance:
0/basal insulin; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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