| Exercise-induced oxidative stress in G6PD-deficient individuals. | |
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MedLine Citation:
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PMID: 16888458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study was designed to investigate whether individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency can exercise without greater perturbations in their redox status compared with non-G6PD-deficient individuals. METHODS: Nine males with established G6PD deficiency and nine males with normal G6PD activity performed two exhaustive treadmill exercise protocols of different duration (the shorter one lasting 12 min and the longer one 50 min). Several hematological parameters, reduced glutathione (GSH), oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), protein carbonyls, catalase, and total antioxidant capacity (TAC) were measured in the blood before and after each exercise bout. RESULTS: Both GSH and GSSG were significantly higher in the control group compared with the G6PD-deficient group at baseline (0.404 +/- 0.101 vs 0.195 +/- 0.049 mmol.L(-1) for GSH and 0.047 +/- 0.012 vs 0.012 +/- 0.006 mmol.L(-1) for GSSG; P < 0.05); as a result, their ratio was not significantly different between the two groups (P > 0.05). All other oxidative stress indices were not different between groups at rest (P > 0.05). Exercise of both durations affected significantly (P < 0.05) and similarly the levels of all oxidative stress indices either in the G6PD-deficient group or in the control group. Only the long exercise affected GSH status significantly (P < 0.05), whereas both short and long exercise increased the levels of TBARS, protein carbonyls, catalase activity, and TAC to a similar extent (P < 0.05). CONCLUSION: G6PD-deficient individuals are able to exercise until exhaustion without higher oxidative stress compared with non-G6PD-deficient individuals. Exercise duration is an important determinant of the magnitude of exercise-induced changes for GSH, GSSG, and GSH/GSSG, but not for TBARS, protein carbonyls, catalase activity, or TAC. |
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Authors:
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Michalis G Nikolaidis; Athanasios Z Jamurtas; Vassilis Paschalis; Iason A Kostaropoulos; Athina Kladi-Skandali; Vera Balamitsi; Yiannis Koutedakis; Dimitris Kouretas |
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Publication Detail:
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Type: Historical Article; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 38 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-04 Completed Date: 2006-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 1443-50 Citation Subset: IM; S |
Affiliation:
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Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Antioxidants / metabolism Catalase / blood Exercise / physiology* Exercise Test Glucosephosphate Dehydrogenase Deficiency / physiopathology* Glutathione Disulfide / blood History, 16th Century Humans Lipid Peroxidation Male Oxidative Stress / physiology* Protein Carbonylation Statistics, Nonparametric Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; 27025-41-8/Glutathione Disulfide; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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