Document Detail


Exercise-induced oxidative stress affects erythrocytes in sedentary rats but not exercise-trained rats.
MedLine Citation:
PMID:  11641336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidant stress is one of the factors proposed to be responsible for damaged erythrocytes observed during and after exercise. The impact of exertional oxidant stress after acute exhaustive treadmill running on erythrocyte damage was investigated in sedentary (Sed) and exercise-trained (ET) rats treated with or without antioxidant vitamins C and E. Exhaustive exercise led to statistically significant increments in the levels of thiobarbituric acid-reactive substance (TBARS) and H2O2-induced TBARS in Sed rats and resulted in functional and structural alterations in erythrocytes (plasma hemoglobin concentrations, methemoglobin levels, and rise in osmotic fragility of erythrocytes with decrease in erythrocyte deformability). Administration of antioxidant vitamin for 1 mo before exhaustive exercises prevented lipid peroxidation (TBARS, H2O2-induced TBARS) in Sed rats without any functional or structural alterations in erythrocytes. Parameters indicating erythrocyte lipid peroxidation and deterioration after exhaustive exercise in rats trained regularly with treadmill running for 1 mo were not different from those in Sed controls. Erythrocyte lipid peroxidation (TBARS) increased in exhausted-ET rats compared with ET controls; however, the plasma hemoglobin, methemoglobin levels, and erythrocyte osmotic fragility and deformability did not differ. Exhaustive exercise-induced lipid peroxidation in ET rats on antioxidant vitamin treatment was prevented, whereas functional and structural parameters of erythrocytes were not different from those of the ET controls. We conclude that exertional oxidant stress contributed to erythrocyte deterioration due to exercise in Sed but not in ET rats.
Authors:
U K Sentürk; F Gündüz; O Kuru; M R Aktekin; D Kipmen; O Yalçin; M Bor-Küçükatay; A Yeşilkaya; O K Başkurt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  91     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-19     Completed Date:  2002-01-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1999-2004     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey. senturk@med.akdeniz.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology
Ascorbic Acid / pharmacology
Body Weight / physiology
Erythrocyte Deformability / physiology
Erythrocytes / physiology*
Hemolysis / physiology
Hydrogen Peroxide / antagonists & inhibitors,  pharmacology
Male
Methemoglobin / metabolism
Organ Size / physiology
Osmotic Fragility / physiology
Oxidants / pharmacology
Oxidative Stress / physiology*
Physical Conditioning, Animal / physiology*
Physical Exertion / physiology*
Rats
Rats, Wistar
Thiobarbituric Acid Reactive Substances / metabolism
Vitamin E / pharmacology
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Oxidants; 0/Thiobarbituric Acid Reactive Substances; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 7722-84-1/Hydrogen Peroxide; 9008-37-1/Methemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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