| Exercise-induced oxidative-nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood-brain barrier leakage. | |
| | |
MedLine Citation:
|
PMID: 21841038 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The present study examined if dynamic cerebral autoregulation (dCA) and blood brain-barrier (BBB) function would become compromised as a result of exercise-induced oxidative-nitrosative stress. Eight healthy males were examined at rest and after an incremental bout of semi-recumbent cycling exercise to exhaustion. Changes in a dynamic cerebral autoregulation index (ARI) were determined during recovery from continuous recordings of blood flow velocity in the middle cerebral artery (MCAv) and mean arterial pressure during transiently induced hypotension. Electron paramagnetic resonance spectroscopy and ozone-based chemiluminescence were employed for direct detection of spin-trapped free radicals and nitric oxide metabolites in venous blood. Neuron-specific enolase (NSE), S100β, and 3-nitrotyrosine (3-NT) were determined by Enzyme-Linked Immuno-Sorbent Assay. While exercise did not alter MCAv, it caused a mild reduction in ARI [6.9 ± 0.6 arbitrary units (AU) to 5.5 ± 0.9 AU, P < 0.05] that correlated directly against the exercise-induced increase in the ascorbate radical, 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide and N-tert-butyl-α-phenylnitrone-adducts, 3-NT and S100β (r = -0.66 to -0.76, P < 0.05). In contrast, no changes in NSE were observed. In conclusion, our findings suggest that intense exercise has the potential to increase BBB permeability without causing structural brain damage subsequent to a free radical-mediated impairment in dCA. |
| | |
Authors:
|
Damian M Bailey; Kevin A Evans; Jane McEneny; Ian S Young; David A Hullin; Philip E James; Shigehiko Ogoh; Philip N Ainslie; Céline Lucchesi; Antal Rockenbauer; Marcel Culcasi; Sylvia Pietri |
Related Documents
:
|
11708138 - Highly sensitive determination of plasma cytokines by time-resolved fluoroimmunoassay; ... 1681408 - Catecholamine responses to acute and chronic exercise. 833078 - Fluid and electrolyte shifts during bed rest with isometric and isotonic exercise. 7821118 - Effects of exercise-induced sympathoadrenergic activation on portal blood flow. 12833428 - Elastic biodegradable poly(glycolide-co-caprolactone) scaffold for tissue engineering. 11796658 - Opposite actions of caffeine and creatine on muscle relaxation time in humans. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-12 |
Journal Detail:
|
Title: Experimental physiology Volume: - ISSN: 1469-445X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1 University of Glamorgan; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adrenergic and Myogenic Regulation of Viscoelasticity in the Vascular Bed of the Human Forearm.
Next Document: Dose-Dependent Disposition of Methotrexate in Abcc2 and Abcc3 Gene Knockout Murine Models.