| Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle. | |
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MedLine Citation:
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PMID: 15294035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise training improves glucose homeostasis through enhanced insulin sensitivity in skeletal muscle. Muscle contraction through physical exercise is a physiological stimulus that elicits multiple biochemical and biophysical responses and therefore requires an appropriate control network. Mitogen-activated protein kinase (MAPK) signalling pathways constitute a network of phosphorylation cascades that link cellular stress to changes in transcriptional activity. MAPK cascades are divided into four major subfamilies, including extracellular signal-regulated kinases 1 and 2, p38 MAPK, c-Jun NH2-terminal kinase and extracellular signal-regulated kinase 5. The present review will present the current understanding of parallel MAPK signalling in human skeletal muscle in response to exercise and muscle contraction, with an emphasis on identifying potential signalling mechanisms responsible for changes in gene expression. |
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Authors:
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Yun Chau Long; Ulrika Widegren; Juleen R Zierath |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Proceedings of the Nutrition Society Volume: 63 ISSN: 0029-6651 ISO Abbreviation: Proc Nutr Soc Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-08-05 Completed Date: 2005-04-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7505881 Medline TA: Proc Nutr Soc Country: England |
Other Details:
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Languages: eng Pagination: 227-32 Citation Subset: IM |
Affiliation:
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Department of Surgical Sciences, Section for Integrative Physiology, Karolinska Institutet, von Eulers väg 4, II, SE-171 77 Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Exercise
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physiology* Humans Mitogen-Activated Protein Kinases / metabolism, physiology* Muscle Contraction Muscle, Skeletal / enzymology* Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.11.24/Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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