Document Detail


Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle.
MedLine Citation:
PMID:  15294035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise training improves glucose homeostasis through enhanced insulin sensitivity in skeletal muscle. Muscle contraction through physical exercise is a physiological stimulus that elicits multiple biochemical and biophysical responses and therefore requires an appropriate control network. Mitogen-activated protein kinase (MAPK) signalling pathways constitute a network of phosphorylation cascades that link cellular stress to changes in transcriptional activity. MAPK cascades are divided into four major subfamilies, including extracellular signal-regulated kinases 1 and 2, p38 MAPK, c-Jun NH2-terminal kinase and extracellular signal-regulated kinase 5. The present review will present the current understanding of parallel MAPK signalling in human skeletal muscle in response to exercise and muscle contraction, with an emphasis on identifying potential signalling mechanisms responsible for changes in gene expression.
Authors:
Yun Chau Long; Ulrika Widegren; Juleen R Zierath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  63     ISSN:  0029-6651     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-08-05     Completed Date:  2005-04-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Affiliation:
Department of Surgical Sciences, Section for Integrative Physiology, Karolinska Institutet, von Eulers väg 4, II, SE-171 77 Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Exercise / physiology*
Humans
Mitogen-Activated Protein Kinases / metabolism,  physiology*
Muscle Contraction
Muscle, Skeletal / enzymology*
Signal Transduction / physiology*
Chemical
Reg. No./Substance:
EC 2.7.11.24/Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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