| Exercise-induced increases in oxidized low-density lipoprotein are associated with adverse outcomes in chronic heart failure. | |
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MedLine Citation:
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PMID: 17996825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Oxidative stress is an important pathophysiologic feature in chronic heart failure (CHF) and may in part result from the inability to counteract acute surges of circulating oxidant products. Oxidized low-density lipoprotein (oxLDL) is an emerging prognostic marker in CHF. Accordingly, we investigated the effect of exercise-induced oxidative stress on circulating levels of oxLDL and its association with clinical outcomes in CHF. METHODS AND RESULTS: Plasma levels of oxLDL and low-density lipoprotein cholesterol (LDL-c) were measured at rest and after maximal exercise in 48 subjects with CHF and 12 healthy controls. Subjects with CHF had a higher baseline oxLDL (77.7 +/- 3.2 U/L vs 57.9 +/- 5.0 U/L, P = .01) and a higher baseline oxLDL/LDL-c ratio (0.87 +/- 0.04 vs 0.49 +/- 0.04, P < or = .001). Exercise induced an increase in oxLDL in subjects with CHF (77.7 +/- 3.2 U/L to 85.3 +/- 3.0 U/L, P < or = .001) but not in controls (57.9 +/- 5.0 to 61.4 +/- 5.5, P = .17). In 39 subjects for whom follow-up data were available, an increase in oxLDL of more than 11.0 U/L was associated with an increased risk to meet a combined end point of death and need for ventricular assist device or heart transplant during a 19-month follow-up period (hazard ratio 8.6; 95% confidence interval 1.0-73.8, P = .05); this remained significant when adjusted for peak oxygen consumption, left ventricular ejection fraction, New York Heart Association class, sex, and age (hazard ratio 46.6, 95% confidence interval 1.5-1438.1, P = .02). CONCLUSION: Plasma oxLDL and the oxLDL/LDL-c ratio are elevated in subjects with CHF. Whether assessment of oxLDL during maximal exercise allows early identification of subjects at highest risk for adverse outcomes should be systematically investigated. |
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Authors:
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Ulrich P Jorde; Paolo C Colombo; Kartikya Ahuja; Alhakam Hudaihed; Duygu Onat; Thomas Diaz; David S Hirsh; Edward A Fisher; Chi-Hong Tseng; Timothy J Vittorio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiac failure Volume: 13 ISSN: 1532-8414 ISO Abbreviation: J. Card. Fail. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-12 Completed Date: 2008-02-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 759-64 Citation Subset: IM |
Affiliation:
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Division of Cardiology, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers Case-Control Studies Cholesterol, LDL / blood* Exercise / physiology* Female Free Radicals Heart Failure / drug therapy*, physiopathology, therapy Humans Lipid Peroxidation Male Middle Aged Oxidative Stress* Oxygen Consumption Prognosis Prospective Studies Stroke Volume Treatment Outcome* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholesterol, LDL; 0/Free Radicals |
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