Document Detail

Exercise-induced increases in myocardial adenosine 3',5'-cyclic monophosphate and phosphodiesterase activity.
MedLine Citation:
PMID:  6260223     Owner:  NLM     Status:  MEDLINE    
Numerous cellular biochemical events caused by hormones are mediated through cyclic AMP. Although many changes occur in the cell during exercise that could be attributed to this nucleotide, little evidence is available implicating it as an important regulator of exercise metabolism. In this investigation it was found that a 60 min bout of treadmill exercise caused a 2.4-fold increase in myocardial cyclic AMP immediately following the work. Rather than the immediate nucleotide hydrolysis that was expected, it was found that the elevated cyclic AMP level remained for approx. 24 h before returning to control levels. Cardiac glycogen fell to 30% of control after work but supercompensated 60% above control within 1 h following exercise. Therefore, cardiac cyclic AMP was elevated at a time when glycogen was being synthesized. Study of the temporal relationship between the exercise-induced increase in cyclic AMP and cyclic nucleotide phosphodiesterase indicated that the work caused an increase in the hearts' capacity to hydrolyze cyclic AMP. Measurement of heart phosphodiesterase at substrate concentrations of 1.0 and 100 microM produced significant increases in enzyme activity immediately following exercise which remained elevated for 48 h and was back to control activity 96 h following work. These data present a potentially fascinating model for the study of the dissociation between cyclic AMP, glycogenesis and elevations in phosphodiesterase activity in the heart.
W K Palmer; T A Studney; S Doukas
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  672     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  114-22     Citation Subset:  IM    
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MeSH Terms
3',5'-Cyclic-AMP Phosphodiesterases / metabolism*
Circadian Rhythm
Cyclic AMP / metabolism*
Glycogen / metabolism
Myocardium / enzymology*,  metabolism
Physical Exertion*
Grant Support
Reg. No./Substance:
60-92-4/Cyclic AMP; 9005-79-2/Glycogen; EC',5'-Cyclic-AMP Phosphodiesterases

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