| Exercise-induced increases in NT-proBNP are not related to the exercise-induced immune response. | |
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MedLine Citation:
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PMID: 18184752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate if the exercise-induced immune response contributes to the exercise-induced increase in brain natriuretic peptide (BNP) in healthy athletes. This has previously been speculated, as elevated concentrations of BNP or N-terminal pro brain natriuretic peptide (NT-proBNP) in cardiovascular patients were found to be related to immune reactions and elevations in inflammatory cytokines such as interleukin 6 (IL-6). METHODS: Stored serum samples were analysed for NT-proBNP concentrations of 14 healthy endurance athletes (mean age: 25 (SD 5) years; VO(2peak) 67 (SD 6) ml/min/kg), who had been examined previously for exercise-induced immune reactions and their dependence on carbohydrate supplementation (6 or 12% carbohydrate vs placebo beverages) after three bouts of 4 h cycling at a given workload of 70% of the individual anaerobic threshold. Venous blood samples were taken before, immediately after, and 1 h and 1 day after exercise. Leucocyte subpopulations were determined immediately after blood sampling by flow cytometry. Serum samples for posterior analysis of C-reactive protein (CRP), IL-6, cortisol and NT-proBNP were stored at -80 degrees C. RESULTS: The exercise-induced increases in NT-proBNP (p<0.001) were not related to the exercise-induced immune response, although exercise induced marked (CHOS-dependent) increases in IL-6, CRP, cortisol, leucocytes, neutrophils, monocytes and natural killer cells. CONCLUSION: It is unlikely that the exercise-induced increases in NT-proBNP or BNP in healthy athletes are caused by the exercise-induced immune response. Therefore, exercise-induced increases in NT-proBNP or BNP in healthy athletes have to be differentiated from increases in cardiovascular patients with systemic inflammation. |
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Authors:
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J Scharhag; T Meyer; M Auracher; M Müller; M Herrmann; H Gabriel; W Herrmann; W Kindermann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-09 |
Journal Detail:
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Title: British journal of sports medicine Volume: 42 ISSN: 1473-0480 ISO Abbreviation: Br J Sports Med Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-07 Completed Date: 2008-06-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0432520 Medline TA: Br J Sports Med Country: England |
Other Details:
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Languages: eng Pagination: 383-5 Citation Subset: IM |
Affiliation:
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Institute of Sports and Preventive Medicine, Campus, Building B 8.2, University of Saarland, 66123 Saarbrücken, Germany. j.scharhag@mx.uni-saarland.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Enzyme-Linked Immunosorbent Assay Exercise / physiology* Flow Cytometry Humans Leukocytes / immunology* Natriuretic Peptide, Brain / metabolism* Peptide Fragments / metabolism Physical Endurance / physiology* Sports / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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