Document Detail

Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats.
MedLine Citation:
PMID:  15604297     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to test the hypothesis that exercise training improves microvascular function in obese Zucker rats, a model of obesity and type II diabetes. Animals were divided into four age-matched groups: lean sedentary (LS), lean exercise (LE), obese sedentary (OS), and obese exercise (OE). The exercise groups were treadmill-exercised from 5 to 11 wk of age, including a 2-wk acclimation period. Mean arterial pressure (MAP) was not significantly different between any of the groups. The OS had significantly higher mean body weight, blood glucose, insulin, IL-6, and leptin levels compared with the LS, whereas the OE had significantly lower blood glucose, insulin, and IL-6 levels compared with the OS. Functional hyperemia and endothelial-dependent vasodilation were tested in the spinotrapezius muscle using intravital microscopy. Functional hyperemia and acetylcholine (0.1 microM, 1 microM, and 10 microM) responses were significantly attenuated in OS compared with the LS, while the contraction and ACh-induced (1 microM and 10 microM) vasodilation were significantly increased in both LE and OE compared with the sedentary animals. These results suggest that exercise training can improve vascular function in this model of type II diabetes. Moreover, the impaired vasodilation observed in 11-wk-old OZR suggests that the microvascular dysfunction is not likely due to an elevated blood pressure.
Lusha Xiang; Jay Naik; Robert L Hester
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-12-16
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  288     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-28     Completed Date:  2005-04-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R987-91     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St., Jackson, MI 39216-4505, USA.
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MeSH Terms
Acetylcholine / metabolism
Arterioles / physiology
Blood Glucose / metabolism
Blood Pressure / physiology
Endothelium, Vascular / physiology
Insulin / blood
Interleukin-6 / blood
Leptin / blood
Muscle Contraction / physiology
Muscle, Skeletal / blood supply*,  metabolism,  physiology*
Muscle, Smooth, Vascular / physiology
Obesity / physiopathology*
Physical Conditioning, Animal / physiology*
Physical Exertion / physiology*
Rats, Zucker
Regional Blood Flow / physiology
Vasodilation / physiology*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Interleukin-6; 0/Leptin; 11061-68-0/Insulin; 51-84-3/Acetylcholine

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