| Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats. | |
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MedLine Citation:
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PMID: 15604297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to test the hypothesis that exercise training improves microvascular function in obese Zucker rats, a model of obesity and type II diabetes. Animals were divided into four age-matched groups: lean sedentary (LS), lean exercise (LE), obese sedentary (OS), and obese exercise (OE). The exercise groups were treadmill-exercised from 5 to 11 wk of age, including a 2-wk acclimation period. Mean arterial pressure (MAP) was not significantly different between any of the groups. The OS had significantly higher mean body weight, blood glucose, insulin, IL-6, and leptin levels compared with the LS, whereas the OE had significantly lower blood glucose, insulin, and IL-6 levels compared with the OS. Functional hyperemia and endothelial-dependent vasodilation were tested in the spinotrapezius muscle using intravital microscopy. Functional hyperemia and acetylcholine (0.1 microM, 1 microM, and 10 microM) responses were significantly attenuated in OS compared with the LS, while the contraction and ACh-induced (1 microM and 10 microM) vasodilation were significantly increased in both LE and OE compared with the sedentary animals. These results suggest that exercise training can improve vascular function in this model of type II diabetes. Moreover, the impaired vasodilation observed in 11-wk-old OZR suggests that the microvascular dysfunction is not likely due to an elevated blood pressure. |
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Authors:
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Lusha Xiang; Jay Naik; Robert L Hester |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2004-12-16 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 288 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-28 Completed Date: 2005-04-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R987-91 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St., Jackson, MI 39216-4505, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism Animals Arterioles / physiology Blood Glucose / metabolism Blood Pressure / physiology Endothelium, Vascular / physiology Insulin / blood Interleukin-6 / blood Leptin / blood Muscle Contraction / physiology Muscle, Skeletal / blood supply*, metabolism, physiology* Muscle, Smooth, Vascular / physiology Obesity / physiopathology* Physical Conditioning, Animal / physiology* Physical Exertion / physiology* Rats Rats, Zucker Regional Blood Flow / physiology Vasodilation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-51971/HL/NHLBI NIH HHS; HL-63958/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Interleukin-6; 0/Leptin; 11061-68-0/Insulin; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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